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Diagnostic Pathology Lab
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A lab that carries out pathological diagnosis while investigating the mechanisms behind the diversity of diseases such as cancer.
AboutAbout the lab
Exploring the diversity of cancer from the front line of pathological diagnosis
The lab works on pathological diagnosis and pathology research, focusing on human pathology and surgical pathology.
Pathological diagnosis is a medical act involved in deciding treatment plans and evaluating the appropriateness of surgery, and it is fundamental to treating diseases including cancer.
In pathology research, the lab analyzes the mechanisms that generate disease diversity from the perspective of tumor stem cells, using histopathological and molecular biological approaches.
The lab traces its origin to the Pathology Division of the Lung Cancer Research Facility; it passed through the Basic Pathology lab and became the current Diagnostic Pathology lab in 2005.
Key terms
- Pathological diagnosis
- A diagnosis in which collected tissue or cells are examined under a microscope to determine the nature and extent of a disease
- Tumor stem cells
- Cells within a tumor that keep proliferating and serve as the source that creates the tumor itself
- Immunostaining
- A method that uses antibodies to show, by color, where a specific protein is located within tissue
ResearchResearch themes
The lab carries out pathological diagnosis work and pathology research, centered on human pathology and surgical pathology. Besides investigating the mechanisms of cancer diversity from the perspective of tumor stem cells, it also takes part in research on digital pathology images and artificial intelligence led by the Japanese Society of Pathology.
*Illustrative imageCollecting Digital Pathology Images
The lab participates as a collaborating research institution, together with the University Hospital's Pathology Department, in the Japanese Society of Pathology's research on digital pathology images (P-WSI). It registers the hospital's P-WSI on the society's cloud server and conducts research with an eye to developing artificial intelligence and other tools.
*Illustrative imageDeveloping AI to Support Pathological Diagnosis
The lab joins, as a co-investigator institution, a study led by the Japanese Society of Pathology in which facilities nationwide participate. Using the collected images, it aims to develop artificial intelligence that supports pathological diagnosis and e-learning materials for training pathologists.
*Illustrative imageFactors That Control Tumor Heterogeneity
Tumor stem cells within a cancer are thought to cause recurrence and metastasis. Focusing on 'plasticity,' through which cells that are not tumor stem cells give rise to tumor stem cells, the lab analyzes the factors that control it by immunostaining pathological specimens.
MembersFaculty
The lab's members consist of faculty, physicians in specialty training, graduate students, visiting researchers, and administrative assistants.
- ProfessorJunichiro Ikeda
- Assistant ProfessorMasayuki Ota
- Assistant ProfessorRei Hashimoto
- Assistant ProfessorSakurako Kagitani
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Pathology department at the central cancer research laboratories” Unknown photographer / Public domain (cropped)
- Collecting Digital Pathology Images: “Clinical Pathology Blood Testing Laboratory in Navi Mumbai, India” Goleisureintl / CC BY 4.0 (cropped)
- Developing AI to Support Pathological Diagnosis: “BalticServers data center” BalticServers.com / CC BY-SA 3.0 (cropped)
- Factors That Control Tumor Heterogeneity: “Granulosa Cell Tumor of the Ovary, Calretinin Immunostain ( )” Ed Uthman from Houston, TX, USA / CC BY 2.0 (cropped)
- Related lab (病態病理学): “Charity Hospital Pathology Dept 1889 NOLA” Photographer not credited / Public domain (cropped)
- Related lab (臨床腫瘍学): “Chemotherapy drug” Larry Ostby (Photographer) / Public domain (cropped)
- Related lab (和漢診療学): “Chinese Medicine” Dr. Bret Mosher / CC BY-SA 4.0 (cropped)
- Related lab (感染生体防御学): “Plasmodium falciparum 01” Photo Credit: Content Providers(s): CDC/Dr. Mae Melvin Transwiki approved by: w:en:User:Dmcdevit / Public domain (cropped)
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