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Bacterial Pathogen Control Lab
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The lab seeks to uncover how infectious diseases arise by studying the toxins that bacteria produce.
AboutAbout the lab
Uncovering the molecular mechanisms of bacterial infection
The Bacterial Pathogen Control Lab aims to uncover the molecular mechanisms by which bacterial infection occurs.
Focusing on toxins, a representative product of bacteria, the lab investigates a broad range of questions, from the changes in the cells that toxins attack to the disease state of the infected individual.
The lab also works to elucidate how the body defends itself against bacteria, with the goal of applying this knowledge to the treatment and prevention of infectious diseases.
The lab conducts joint research with universities and research institutions in Japan and abroad, pharmaceutical-related companies, and clinical physicians.
Key terms
- Shiga toxin
- A toxin produced by bacteria such as enterohemorrhagic E. coli. It is considered the main cause of severe symptoms.
- Enterohemorrhagic Escherichia coli
- A type of E. coli that can establish infection with only a small number of bacteria and causes symptoms such as bloody stool.
- Type III secretion system
- A mechanism by which bacteria use a needle-like apparatus to inject their own proteins directly into a target cell.
NewsLab news
View More ↗ResearchResearch themes
The lab aims to identify the virulence factors that bacteria carry and clarify how they work, and to search for substances that suppress their action. Using enterohemorrhagic Escherichia coli as its main model, the lab studies toxins and the establishment of infection.
*Illustrative imageRelease mechanisms of Shiga toxin
Shiga toxins produced by enterohemorrhagic E. coli come in two closely related forms, Stx1 and Stx2. The lab has investigated how the toxins are sorted to the inside and outside of the bacterial cell after production, and has shown that Stx2 has two types of release mechanism.
*Illustrative imageHow infection becomes established
Enterohemorrhagic E. coli attaches to intestinal epithelial cells using a type III secretion system. The lab found that Shiga toxin production increases upon attachment, and is analyzing the mechanism behind this as well as how the bacteria sense that they have attached.
MembersFaculty
The lab's members are faculty, graduate students, collaborative researchers, and technical assistants.As of 2026
- Associate ProfessorTakeshi Shimizu
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Escherichia coli O157-H7 CDC ID-10071” CDC / Janice Haney Carr / Public domain (cropped)
- Release mechanisms of Shiga toxin: “PDB 1r4p EBI” Jawahar Swaminathan and MSD staff at the European Bioinformatics Institute / Public domain (cropped)
- How infection becomes established: “E coli at 10000x, original” Photo by Eric Erbe, digital colorization by Christopher Pooley, both of USDA, ARS, EMU. / Public domain (cropped)
- Related lab (Organ Regulatory Surgery Lab): “USAF surgical team help inaugurate new operating rooms in Suriname (8257392)” U.S. Air Force photo by Tech. Sgt. Rachel Maxwell / Public domain (cropped)
- Related lab (Tumor Pathology Lab): “Scanning electron microscope - UFCH JH (2020) 01” Tadeáš Bednarz / CC BY-SA 4.0 (cropped)
- Related lab (Infectious Disease Pathogenesis Lab): “SARS-CoV-2 scanning electron microscope image” National Institute of Allergy and Infectious Diseases (NIAID) / CC BY 2.0 (cropped)
- Related lab (Nephrology Lab): “Hemodialysis machine INNOVA” Виталий Поспелов at ru.wikipedia / CC BY-SA 3.0 (cropped)
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