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Public Health Lab
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A lab that finds the genes behind diseases of unknown cause, leading to diagnosis and treatment.
AboutAbout the lab
Finding the genes involved in disease
The Public Health Lab studies how to find genes involved in diseases of unknown cause and intractable diseases.
By identifying genes involved in onset, exacerbation, and response to treatment, the lab aims to elucidate causes, establish diagnostic methods, and realize precision medicine.
The lab targets both multifactorial diseases and monogenic diseases, and several joint projects with clinical departments are underway.
The lab also actively analyzes undiagnosed cases in which a hereditary disease was suspected in various clinical departments.
Key terms
- Multifactorial disease
- A disease caused not by a single gene alone but by multiple genes combined with environmental factors
- Variant
- A difference in genome sequence between individuals, which can affect susceptibility to disease
- Precision medicine
- An approach to medicine that selects treatments likely to be effective based on a person's genetic characteristics
ResearchResearch themes
By identifying genes involved in the onset, exacerbation, and treatment response of diseases of unknown cause and intractable diseases, the lab aims to elucidate causes, establish diagnostic methods, and realize precision medicine. It targets both multifactorial diseases and monogenic diseases, and several joint projects with clinical departments are underway.
*Illustrative imageGenetics of Kawasaki disease
Kawasaki disease is an acute febrile illness of unknown cause that is common in infants and young children, causing inflammation in small and medium-sized arteries throughout the body. The lab aims to identify genomic variants involved in onset, severity, and response to treatment, leading to elucidation of the cause and development of new treatments.
*Illustrative imageInflammatory bowel disease
This is an intractable disease of unknown cause, designated by the Japanese government, in which chronic inflammation and ulcers develop in the mucosa of the digestive tract. The lab aims to clarify the genetic background and the mechanisms of onset, leading to new drugs and new methods of diagnosis and treatment.
*Illustrative imageIndividual differences in vaccine response
Among university hospital staff who received the COVID-19 vaccine, the lab studies the genetic background of individual differences in antibody titers after vaccination. It found that variants in genes related to the heavy chain of neutralizing antibodies are associated with antibody titers.
*Illustrative imageClinical genetics research
This research uses experiments to confirm what changes in gene sequences, found by genetic testing of patients who visited clinical departments of the university hospital, actually mean.
MembersFaculty
The members of the Public Health Lab are faculty, technical specialists, and technical assistants.
- ProfessorYoshihiro Onouchi
- LecturerKeiko Yamazaki
- Assistant ProfessorFumie Takechi
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “DNBSEQ-G400” RPSkokie / CC BY-SA 4.0 (cropped)
- Genetics of Kawasaki disease: “Coronary Artery Bypass Surgery” BruceBlaus / CC BY-SA 4.0 (cropped)
- Inflammatory bowel disease: “Crohn's Disease” BruceBlaus / CC BY-SA 4.0 (cropped)
- Individual differences in vaccine response: “Vero Cell COVID-19 vaccine vial, cotton swab and syringe” Ajay Kumar Chaurasiya / CC BY-SA 4.0 (cropped)
- Clinical genetics research: “Gen-Test im Labor durch eine Biologin” Marc-Lautenbacher / CC BY-SA 4.0 (cropped)
- Related lab (Pathophysiology and Pathology Lab): “Charity Hospital Pathology Dept 1889 NOLA” Photographer not credited / Public domain (cropped)
- Related lab (Environmental and Occupational Health Lab): “Mt. Fuji and Keiyo petrochemical complex” Nanashinodensyaku / CC BY-SA 4.0 (cropped)
- Related lab (Pediatrics Lab): “Haende-30” Matthias Süßen / CC BY-SA 3.0 (cropped)
- Related lab (Experimental Immunology Lab): “T Lymphocyte ( )” NIAID / CC BY 2.0 (cropped)
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