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Regenerative Medicine Lab (TMRC)
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The lab investigates the mechanisms that control the quantity and quality of skeletal muscle.

AboutAbout the lab
Unraveling muscle quantity and quality at the molecular level
The Regenerative Medicine field studies the mechanisms that determine the quantity and quality of skeletal muscle.
Skeletal muscle not only moves the body; it is also the body's largest organ for energy metabolism and an endocrine organ that exchanges signals with other tissues through the bloodstream.
Through its research, the lab aims to develop ways to prevent and treat sarcopenia, the loss of muscle mass and strength with aging.
The field belongs to the Space Medicine Division of the Transborder Medical Research Center at the University of Tsukuba.
Key terms
- Sarcopenia
- Loss of skeletal muscle mass and strength with aging. Reduced muscle strength directly lowers quality of daily life.
- Skeletal muscle stem cell
- Cells essential for skeletal muscle regeneration. They are thought to maintain their properties by working with surrounding cells and their environment (the niche).
- Muscle fiber type
- Types of skeletal muscle cells (muscle fibers). They divide into slow-twitch fibers, suited to endurance, and fast-twitch fibers, which generate force.
ResearchResearch themes
The lab works to uncover the molecular mechanisms that control the quantity and quality of skeletal muscle, with the aim of developing ways to prevent and treat sarcopenia. It also explores the evolutionary background of human skeletal muscle and pursues the possibility of new functional extensions of skeletal muscle.
*Illustrative imageThe environment that supports skeletal muscle stem cells
The lab studies how skeletal muscle stem cells, which are essential for muscle regeneration, interact with surrounding cells and their environment (the niche). It has also developed original mice that visualize differences among individual stem cells, aiming to clarify their physiological significance and apply it to regenerative medicine.
*Illustrative imageHow muscle fiber type is determined
Muscle fibers mature into slow-twitch and fast-twitch types, and their ratio affects muscle strength and fatigue resistance. The lab examines the mechanisms that control muscle fiber type, such as transcription factors, and also focuses on how individual differences in human single nucleotide polymorphisms (SNPs) affect muscle fiber properties and disease risk.
MembersFaculty
- Associate ProfessorRyo Fujita
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Attractive man lifting dumbbell weight for exercise in fitness gym” Nenad Stojkovic / CC BY 2.0 (cropped)
- The environment that supports skeletal muscle stem cells: “Multinuclear muscle fiber cells and some associated mononuclear cells” MethylC5 / CC BY-SA 4.0 (cropped)
- How muscle fiber type is determined: “Muscle Tissue Cross Section Whole Skeletal Muscle ( )” Berkshire Community College Bioscience Image Library / CC0 (cropped)
- Related lab (Sleep Physiology Lab (WPI-IIIS)): “Rapid eye movement sleep behavior disorder” Uguccioni G, Pallanca O, Golmard J, Dodet P, Herlin B, Leu-Semenescu S, Arnulf I / CC BY 4.0 (cropped)
- Related lab (Vascular Matrix Biology (TARA) Lab): “Technicians examine tissue culture” Unknown photographer / Public domain (cropped)
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