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Molecular Reproduction and Development Lab
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A lab that explores the mechanisms of embryo implantation at the molecular level.
AboutAbout the lab
Decoding implantation through the dialogue between embryo and uterus
The Molecular Reproduction and Development Lab focuses on implantation, which occurs at the very beginning of pregnancy, and studies how the embryo and uterus exchange information to create an environment for development.
Implantation is the stage at which the embryo attaches to the uterine lining (endometrium), leading to subsequent placenta formation and embryonic development.
Working mainly with mice, and also comparing mammals with different modes of pregnancy, the lab investigates how conserved molecular signals are used differently in each species.
In the future, the lab hopes to generate findings that contribute to understanding how pregnancy is established and to applications in reproductive medicine.
Key terms
- Implantation
- The early stage of pregnancy in which the embryo attaches to the uterine lining (endometrium). It leads to subsequent placenta formation and embryonic development.
- Multi-omics
- An analytical approach that combines information on multiple types of molecules.
- Prostaglandin
- A type of bioactive lipid. It is a molecule the lab focuses on particularly in its research on the regulation of implantation and pregnancy.
ResearchResearch themes
The lab investigates which molecular signals are exchanged between the embryo and uterus, and how an environment that supports development is created at the site of implantation. By combining multi-omics and functional analyses, it aims to uncover the basic principles that regulate maternal-embryo interactions.
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MembersFaculty
- Associate ProfessorShizu Aikawa
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Microdrop embryo culture dish” S.Y.M.B.I.O.N.T. / CC BY-SA 4.0 (cropped)
- Molecular mechanisms that regulate implantation and pregnancy: “Bicornuate uterus with pregnancy” Drhan9394 / CC0 (cropped)
- Related lab (Molecular Developmental Regulation Lab): “Echinoderm embryo undergoing second cleavage” Bruno C. Vellutini / CC BY-SA 4.0 (cropped)
- Related lab (Genome Information Biology Lab): “ADMA-3D-balls-by-AHRLS-2012” Amir.ahrls / CC0 (cropped)
- Related lab (Animal Resource Production Lab): “Desa Cattle Dairy Farm, Kundasang 28 December 2023 06” Pangalau / CC BY-SA 4.0 (cropped)
- Related lab (Biological Information Regulation Lab): “Fluorescence Microscope ZEISS UNIVERSAL (ca. )” ZEISS Microscopy from Germany / CC BY-SA 2.0 (cropped)
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