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Genome Information Biology Lab
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A lab that explores the mechanisms of metabolism and gene expression through protein methylation.
AboutAbout the lab
Using methylation as a clue to decode metabolism and gene expression.
The Genome Information Biology Lab studies how signals related to lifestyle, such as diet, hormones, and stress, change the activity of genes both inside and outside the cell.
Focusing on modifications such as methylation that are added to proteins, the lab aims to understand at the molecular level how lifestyle-related diseases arise and how life processes work.
Using cultured cells, mice, and nematodes, the lab investigates mechanisms involved in lifespan, aging, and blood pressure regulation, among other topics.
On the lab's website, it is introduced under the name "Fukamizu Lab."
Key terms
- Arginine methylation
- A modification in which a methyl group is added to the amino acid arginine after a protein has been made. It is carried out by PRMT enzymes.
- Nematode
- A simple multicellular animal about 1 mm long. Its short lifespan and ease of genetic analysis make it widely used in research on lifespan and aging.
- Renin-angiotensin system
- A mechanism in which enzymes and hormones produced in the liver and kidneys act in sequence to regulate blood pressure and the body's balance of water and salt.
NewsLab news
A master's student won the Judges' Special Award in the logo design competition for the 100th anniversary of the Japanese Biochemical Society
A master's student won an excellent poster award at TGSW2024
A PhD student's paper won the JB Paper Award of the Japanese Biochemical Society
A PhD student won an Excellence Award in the Certificate for Outstanding Foreign-Language Activities
ResearchResearch themes
This lab aims to understand a wide range of unknown life phenomena, centered on protein methylation. Besides the representative results below, in recent years the lab has taken on a broad range of interesting themes: discoveries that bring us closer to elucidating histidine methylation, which is still largely unexplained; the discovery that a one-amino-acid difference in an arginine methyltransferase between mice and humans causes differences in immunity; methyltransferases that act outside cells as well as inside them; and the interplay between methylation and other modifications.
*Illustrative imageHow nutrition affects lifespan and aging
The lab investigates how changes in nutritional state, such as starvation and overeating, affect lifespan and aging. It explores the mechanisms in nematodes, which are easy to analyze genetically, and confirms the results in mice.
*Illustrative imageThe role of arginine methylation in the body
The lab investigates the roles that protein arginine methylation plays in living organisms. It creates and analyzes mice in which the gene for PRMT, the enzyme responsible for this reaction, is deleted only in specific tissues.
*Illustrative imageHow blood pressure is maintained and how it breaks down
The lab studies the hormone and receptor mechanisms that keep blood pressure constant, using genetically modified mice. Centered on the renin-angiotensin system, it examines the regulation of normal blood pressure and hypertension, and the relationship to diseases of pregnancy.
MembersFaculty
The members of the Genome Information Biology Lab consist of faculty, visiting faculty and researchers, postdoctoral researchers, part-time researchers, PhD, master's, and undergraduate students, technical assistants, and a secretary.
- Specially Appointed ProfessorAkiyoshi Fukamizu
- Associate ProfessorHiroaki Daitoku
- LecturerKoichiro Kako
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “ADMA-3D-balls-by-AHRLS-2012” Amir.ahrls / CC0 (cropped)
- How nutrition affects lifespan and aging: “Adult Caenorhabditis elegans” The original uploader was Kbradnam at English Wikipedia. (Original text: Zeynep F. Altun, Editor of www.wormatlas.org) / CC BY-SA 2.5 (cropped)
- The role of arginine methylation in the body: “Arginine-3D-balls-by-AHRLS-2012” Amir.ahrls / CC0 (cropped)
- How blood pressure is maintained and how it breaks down: “Blood pressure monitoring” rawpixel.com / CC0 (cropped)
- Related lab (Biological Function Regulation Lab): “Vintage students laboratory (1904), Gdansk University of Technology, Poland” LukaszKatlewa / CC BY-SA 4.0 (cropped)
- Related lab (Food Resource Utilization Science Lab): “Semi-desert vegetation in Lamu” HassanA2023 / CC BY-SA 4.0 (cropped)
- Related lab (Natural Products Chemistry Lab): “Ecological Trail Garden of Medicinal and Aromatic Plants and South China Medicinal Plants Garden )” LN9267 / CC BY-SA 4.0 (cropped)
- Related lab (Molecular Reproduction and Development Lab): “Microdrop embryo culture dish” S.Y.M.B.I.O.N.T. / CC BY-SA 4.0 (cropped)
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