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Molecular Developmental Regulation Lab
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A lab that investigates the regulation of processes from sperm and egg formation through fertilization and early embryonic development.
AboutAbout the lab
Unraveling the regulation of sperm and egg formation and fertilization
The Molecular Developmental Regulation Lab studies how gene transcription and translation are regulated during the formation of gametes such as sperm and eggs.
It identifies regulatory factors involved in fertilization, egg activation, and the subsequent early embryonic development, and investigates how they function.
The lab also works on developing next-generation reproductive and developmental technologies.
Key terms
- Gametes
- Cells such as sperm and eggs that fuse at fertilization to form the next generation
- Translation
- The process by which proteins are made from mRNA, the copy of genetic information
- Egg activation
- The switch of an egg, triggered by fertilization, into a state in which it begins development
NewsLab news
View More ↗ResearchResearch themes
The lab investigates the regulation of gene transcription and translation during the formation of sperm and eggs, as well as the regulatory factors involved in the process from fertilization to early embryonic development. It identifies these factors and analyzes their functions, and also works on developing next-generation reproductive and developmental technologies.
*Illustrative imageGene regulation in sperm and egg formation
The lab analyzes how gene transcription and translation are regulated during gamete formation. In spermatogenesis, it also focuses on regulation mediated by the poly(A) tail of mRNA.
*Illustrative imageRegulatory factors in fertilization and early embryonic development
The lab identifies regulatory factors involved in fertilization, egg activation, and early embryonic development, and analyzes their functions.
*Illustrative imageDeveloping next-generation reproductive and developmental technologies
The lab also conducts research to develop next-generation technologies in the fields of reproduction and development.
MembersFaculty
- Associate ProfessorShinichi Kashiwabara
- Assistant ProfessorYoshinori Kanemori
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Echinoderm embryo undergoing second cleavage” Bruno C. Vellutini / CC BY-SA 4.0 (cropped)
- Gene regulation in sperm and egg formation: “Metaphase meiosis II” OlgaMaliuta / CC BY-SA 4.0 (cropped)
- Regulatory factors in fertilization and early embryonic development: “Frog eggs 4” VinetVas17 / CC BY-SA 4.0 (cropped)
- Developing next-generation reproductive and developmental technologies: “Toolholder of a micromanipulator” Fjvv73. Original uploader was Fjvv73 at English Wikipedia / CC BY-SA 3.0 (cropped)
- Related lab (Molecular Reproduction and Development Lab): “Microdrop embryo culture dish” S.Y.M.B.I.O.N.T. / CC BY-SA 4.0 (cropped)
- Related lab (Plant Genetic Information Analysis Lab): “The budding Seedling” Martin Stübler / CC BY-SA 4.0 (cropped)
- Related lab (Insect Semiochemistry Lab): “European honey bee extracts nectar” John Severns (Severnjc) / Public domain (cropped)
- Related lab (Animal Resource Production Lab): “Desa Cattle Dairy Farm, Kundasang 28 December 2023 06” Pangalau / CC BY-SA 4.0 (cropped)
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