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Animal Resource Production Lab
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A lab that explores the mechanisms of animal reproduction at the molecular and cellular levels.
AboutAbout the lab
Investigating the "why" of animal reproductive mechanisms scientifically
The Animal Resource Production Lab works to elucidate the molecular basis that controls reproductive mechanisms in animals, aiming to develop new livestock production and reproductive medicine technologies.
The lab studies how sperm acquire the ability to fertilize while altering their plasma membrane, and how sperm mature in the epididymis.
It also works on elucidating the mechanism of reprogramming, in which iPS cells are generated from somatic cells.
On the lab's website, it is introduced under the name "Asano Lab."
Key terms
- Membrane raft microdomain
- A small region of the plasma membrane rich in sterols, ganglioside GM1, and functional membrane proteins
- Epididymis
- The organ that sperm formed in the testis pass through. While passing through it, their plasma membrane changes and they acquire the ability to fertilize
- iPS cells
- Undifferentiated cells created by artificially reprogramming specific cells. In laboratory animals, whole individuals have even been successfully regenerated from them
ResearchResearch themes
Although reproductive engineering technologies have advanced in recent years, problems remain for which no clue to a solution has been found, such as unexplained infertility in humans and declining conception rates in artificial insemination of cattle. This lab works to elucidate the molecular basis that controls animal reproductive mechanisms and, building on the results, aims to develop new livestock production and reproductive medicine technologies.
*Illustrative imageThe role of membrane rafts in fertilization
The lab studies the role played in sperm and fertilized eggs by "membrane raft microdomains," small regions of the plasma membrane rich in sterols and other components. Based on the findings, it is also developing technologies to control fertilizing ability.
*Illustrative imageHow sperm mature
While passing through the epididymis, sperm take functional proteins and lipids from the external environment into their plasma membrane and acquire the ability to fertilize. The lab works to elucidate this mechanism of epididymal maturation and to identify the causes of male infertility.
*Illustrative imagePreserving animal genetic resources using stem cells
The lab works to fully elucidate the mechanism by which somatic cells are reprogrammed into iPS cells. It is also developing the supporting technologies needed to regenerate wild animals using iPS cells.
MembersFaculty
- Associate ProfessorAtsushi Asano
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Desa Cattle Dairy Farm, Kundasang 28 December 2023 06” Pangalau / CC BY-SA 4.0 (cropped)
- The role of membrane rafts in fertilization: “Sperm-egg” 作者不詳 / Public domain (cropped)
- How sperm mature: “A Pathway to Protocells on Titan – Animations (SVS -Cell-Membrane-Thumbnail)” NASA's Scientific Visualization Studio - NASA Goddard / Public domain (cropped)
- Preserving animal genetic resources using stem cells: “Liquid nitrogen tank for cryostorage-07” real name: Matylda Sęk pl.wiki: Cygaretka commons: Cygaretka / CC BY-SA 3.0 (cropped)
- Related lab (Plant Breeding Lab): “Cucumis melo - Диня - Український сорт Забавка” Zenon Sych / CC BY-SA 4.0 (cropped)
- Related lab (Soil Environmental Chemistry Lab): “CSIRO ScienceImage 712 Soil Profiling India” T.Grove, CSIRO / CC BY 3.0 (cropped)
- Related lab (Natural Products Chemistry Lab): “Ecological Trail Garden of Medicinal and Aromatic Plants and South China Medicinal Plants Garden )” LN9267 / CC BY-SA 4.0 (cropped)
- Related lab (Forest Ecology and Environment / Regional Resource Conservation Lab): “White Desert, Desert landscape, Egypt” Vyacheslav Argenberg / CC BY 4.0 (cropped)
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