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Biological Information Regulation Lab
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A lab that explores how chromosomes are formed and segregated during cell division.
AboutAbout the lab
Revealing at the molecular level how chromosomes are divided accurately.
The Biological Information Regulation Lab studies at the molecular level how chromosomes are formed and divided equally during cell division.
Chromosomes in mitosis are huge complexes assembled from DNA, RNA, and proteins.
Abnormalities in the replication or segregation of chromosomes are thought to lead to a variety of diseases, including cell death and cancer.
On the lab's website, it is also introduced under the name "Kimura Lab."
Key terms
- Condensin
- A major protein component of mitotic chromosomes, thought to be involved in chromosome condensation and segregation.
- Liquid-liquid phase separation
- A phenomenon in which a solution does not mix uniformly but separates into two phases. It is involved in processes such as the formation of membraneless structures.
- Nucleolus
- A membraneless structure inside the nucleus. It is known as the site of ribosomal RNA transcription and ribosome biogenesis.
ResearchResearch themes
For the cells of the body to keep the same genetic information, chromosomes must be replicated accurately and distributed equally from the parent cell to the daughter cells during mitosis. This lab investigates at the molecular level how mitotic chromosomes, which are huge complexes of DNA, RNA, and proteins, are formed and segregated.
*Illustrative imageThe role of RNA localized on chromosomes
Mitotic chromosomes also contain noncoding RNAs, which do not produce proteins. The lab found that removing RNA makes the chromosome axis thin and fragile and causes major scaffold proteins to dissociate. Under a model in which liquid-liquid phase separation is involved, it aims to identify the RNAs that promote this.
*Illustrative imageInteraction between PP2A and condensin
The phosphatase PP2A has been found to act not only as an enzyme but also to help bind condensin II and other factors to chromosomes. The lab aims to examine, using cultured cells and Xenopus egg extracts, how this relationship affects the progression of mitosis and chromosome movement.
*Illustrative imageSearching for interacting factors with proximity-dependent labeling
The lab is searching for proteins that interact with condensin and the SMC5/6 complex. By making cells express fusion proteins with a biotinylating enzyme, which attaches biotin to nearby proteins so that they can be recovered, it aims to uncover unknown roles of these complexes.
*Illustrative imageControl of mitosis by SNRNP200
The lab focuses on SNRNP200, which was found in a screen of nucleolar proteins. It has shown that reducing the amount of this protein in cells with siRNA causes chromosome cohesion defects and multipolar spindles, which hinder the progression of cell division.
MembersFaculty
The members of the Kimura Lab consist of faculty, master's and undergraduate students, and a secretary.
- ProfessorKeiji Kimura
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Fluorescence Microscope ZEISS UNIVERSAL (ca. )” ZEISS Microscopy from Germany / CC BY-SA 2.0 (cropped)
- The role of RNA localized on chromosomes: “Células de cebolla aumento total 100X en división celular” BioGenZambrano / CC BY-SA 4.0 (cropped)
- Interaction between PP2A and condensin: “Kinetochore” Afunguy / Public domain (cropped)
- Searching for interacting factors with proximity-dependent labeling: “LTQ OrbiTrap XL-Thermo Scientific 1” real name: Nadina Wiórkiewicz pl.wiki: Nadine90 commons: Nadine90 / CC BY-SA 3.0 (cropped)
- Control of mitosis by SNRNP200: “Sterile 24-Well Cell Culture Plate Used in Laboratory Research” Gannu03 / CC BY-SA 4.0 (cropped)
- Related lab (Cell Function Development Engineering Lab): “Small cell culture flat flask” Lilly_M / CC BY-SA 3.0 (cropped)
- Related lab (Food Functional Chemistry Lab): “Tissue glass Dounce homogenizer-03” Lilly_M / CC BY-SA 3.0 (cropped)
- Related lab (Microbial Breeding Engineering Lab): “Large oak fermentation tanks” David / CC BY 2.0 (cropped)
- Related lab (Genome Information Biology Lab): “ADMA-3D-balls-by-AHRLS-2012” Amir.ahrls / CC0 (cropped)
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