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分子細胞生化学分野
Showing the original Japanese · View translation
創薬の標的となるGPCRのシグナル伝達を解き明かす研究室。
AboutAbout the lab
Gタンパク質共役型受容体を、構造・細胞・個体で理解する。
分子細胞生化学分野は、
構造・細胞・個体の
培養細胞で
井上教授は、
Key terms
- Gタンパク質共役型受容体
（GPCR） - 細胞膜に
ある 受容体。 ホルモンなど 細胞の 外の 物質を 感知する センサーと して 働く - 三量体Gタンパク質
- GPCRが
活性化されると 細胞内で 働く 信号伝達分子。 Gs、 Gi、 Gq、 G12に 大別される - デザイナーGPCR
- もとの
リガンドには 応答せず、 特定の 人工リガンドに より 活性化される 人工の GPCR
NewsLab news
博士課程の
学生が 筆頭著者の 論文が、 Eur J Pharmacol 誌に 掲載 博士課程の
学生が 筆頭著者の 論文が、 Biochim Biophys Acta Mol Basis Dis 誌に 掲載 学部の
学生が、 第97回日本生化学会大会で 若手優 秀発表賞を 受賞 修士課程の
学生が 筆頭著者の 論文が、 Biophysics and Physicobiology 誌に 掲載 助教が
筆頭著者の 論文が、 Genes Cells 誌に 掲載
ResearchResearch themes
この
*Illustrative imageGPCRシグナルを測る検出法の開発
Gqや
*Illustrative imageGPCRとGタンパク質の共役データベース
TGFα切断アッセイで、
*Illustrative imageG12の働きを調べる人工受容体
G12に
*Illustrative imageシグナルの時間変化を追う検出法
高輝度の
MembersFaculty
分子細胞生化学分野の
- Professor井上 飛鳥
- Associate Professor柳川 正隆
- Assistant Professor生田 達也
- Project Assistant Professor木瀬 亮次
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薬理学分野薬学部 薬学科・創薬科学科記憶やThe information on this page is compiled by the LabLog team from the lab's public information and interviews. For corrections or removal requests, please contact LabLog, not the lab.
Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “NEUROTENSIN RECEPTOR 2” rcsb pdb / CC BY 4.0 (cropped)
- GPCRシグナルを
測る 検出法の 開発: “Smartphone colorimetry – 96-well microplate with serial dilutions of coloured solutions” Mdc-science / CC BY-SA 4.0 (cropped) - GPCRと
Gタンパク質の 共役データベース: “PDC server room” Esquilo / CC BY-SA 3.0 (cropped) - G12の
働きを 調べる 人工受容体 : “Aripiprazole bound to Dopamine D2 Receptor docking model” EpsilonVisuals / CC BY-SA 4.0 (cropped) - シグナルの
時間変化を 追う 検出法: “Use of a Multichannel Pipette for High-Throughput Liquid Handling in a Biosafety Cabinet” Siduduziwe Nxumalo / CC BY-SA 4.0 (cropped) - Related lab (衛生化学分野): “Onion cells under the fluorescence microscope 3” Kateryna Kot / CC BY-SA 4.0 (cropped)
- Related lab (生体統御システム学分野): “Red Fluorescence Microscopy” Jamil Baza / CC BY 4.0 (cropped)
- Related lab (生物構造化学分野): “Optical microscope for the study of paint fragments” Froselong / CC BY-SA 4.0 (cropped)
- Related lab (薬理学分野): “GnRH Neuron” B. Ian Hutchins and Susan Wray / Public domain (cropped)
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