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Tumor Biomedical Engineering Lab
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The lab uses nanotechnology to explore the mechanisms and treatment of lymph node metastasis.
AboutAbout the lab
Unraveling lymph node metastasis through nanotechnology that combines engineering and medicine
The Tumor Biomedical Engineering Lab (Kodama Lab) focuses on the lymph nodes, where metastasis is found in many cancer patients, and studies the mechanisms and treatment of lymph node metastasis.
Lymph node metastasis offers clues about how a cancer will progress, but its mechanisms are still not understood.
The lab is developing the lymphatic drug delivery system (LDDS), a method that injects anticancer drugs directly into a lymph node and delivers them to the downstream lymph nodes.
The lab has created its own “enlarged lymph node mouse,” which has lymph nodes the same size as those of humans, and uses it in its research.
Key terms
- Lymph node metastasis
- Cancer cells travel through lymphatic vessels to lymph nodes and grow there. It is seen in many types of cancer
- Sentinel lymph node
- The first lymph node that cancer cells reach from the original tumor. This node is examined or treated
- Lymphatic drug delivery system
- A method that injects an anticancer drug directly into a lymph node and carries it to downstream lymph nodes with the flow of the lymphatic vessels. Abbreviated as LDDS
- Lymph node dissection
- Surgery to remove lymph nodes suspected of containing metastases
NewsLab news
Prof. Kodama received the 19th Mizushima Award from the Japan Society of Drug Delivery System
An Assistant Professor received the Journal Award at the 42nd Annual Meeting of the Japan Society of Drug Delivery System
An Assistant Professor received the Encouragement Award (Nishi Award) at the 50th General Meeting of the Japanese Society of Lymphology
A paper by Master's students and others was published in The Journal of Controlled Release
A paper by an Assistant Professor and others was published in The Journal of Pathology
ResearchResearch themes
The lab combines engineering and medicine to clarify the mechanisms of lymph node metastasis and create new cancer treatments. It examines the routes of metastasis via lymph nodes, drug delivery to lymph nodes, and changes in cancer cells after lymph node removal.
*Illustrative imageVerifying Metastasis via Lymph Nodes
The lab proposes the “lymph node-mediated hematogenous metastasis theory”: in the early stage of metastasis, cancer cells enter the veins of the sentinel lymph node and spread to organs throughout the body through the bloodstream. It aims to confirm this theory experimentally.
*Illustrative imageLymphatic Drug Delivery System (LDDS)
The lab aims to inject anticancer drugs directly into the sentinel lymph node and also treat metastases in the lymph nodes downstream of it. The amount of anticancer drug needed is expected to be markedly smaller than with systemic chemotherapy.
*Illustrative imageCancer Activation after Lymph Node Dissection
Clinical cases have been reported in which cancer cells that had metastasized to distant organs became activated after lymph node dissection. Using a mouse model of lung metastasis activation developed in the lab, the lab studies the link between dissection and the activation of lung metastases.
MembersFaculty
The members of the Tumor Biomedical Engineering Lab (Kodama Lab) consist of faculty, part-time lecturers, research fellows, doctoral, master's, and undergraduate students, and a secretary.As of 2026
- ProfessorTetsuya Kodama
- Assistant ProfessorAriunbuyan Sukhbaatar
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Flask of cancer cells on inverted microscope” Mateus Figueiredo / CC BY-SA 4.0 (cropped)
- Verifying Metastasis via Lymph Nodes: “3D medical animation TNM Staging System” https://www.scientificanimations.com / CC BY-SA 4.0 (cropped)
- Lymphatic Drug Delivery System (LDDS): “Hand holds a syringe near lab equipment in a science lab” Shixart1985 / CC BY 2.0 (cropped)
- Cancer Activation after Lymph Node Dissection: “Operating room” John Crawford (Photographer) / Public domain (cropped)
- Related lab (Molecular and Regenerative Prosthodontics Lab): “Disc with dental implants made with WorkNC” Sescoi CAD/CAM / CC BY-SA 2.0 (cropped)
- Related lab (Oral Pathology Lab): “Hooke Microscope-03000276-FIG-4” 作者不詳 / Public domain (cropped)
- Related lab (Orthodontics Lab): “Gipsabguss Gebiss” Sciencia58 / CC0 (cropped)
- Related lab (Advanced Free Radical Control Joint Research Lab): “US Navy 050920-N-3188P-008 U.S. Navy Dental Technician 2nd Class Barbara J. Edenfield, assigned to Naval Branch Health Clinic Jacksonville, waxes a hard night guard” U.S. Navy photo by Photographer's Mate 2nd Class Jamar X Perry / Public domain (cropped)
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