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Molecular and Regenerative Prosthodontics Lab
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A lab that studies prosthodontic treatment for replacing teeth from the perspectives of molecular science and regenerative medicine.
AboutAbout the lab
Understanding treatments that replace teeth at the molecular level.
The Molecular and Regenerative Prosthodontics Lab studies prosthodontics, the replacement of lost teeth with artificial materials, from the perspectives of molecular biology, biomaterials science, and regenerative medicine.
The lab is in charge of crown and bridge prosthodontics at the undergraduate level, and it also provides treatment such as crowns, bridges, and implants at the Department of Occlusal Restoration of Tohoku University Hospital.
The "Molecular and Regenerative" in the lab's name reflects the intention to respect conventional prosthodontics while introducing molecular interpretations from biology, materials science, and physical chemistry, together with regenerative medicine.
The professor describes the lab as a gathering of members who are interested in creating new things.
Key terms
- Prosthodontics
- Treatment that replaces lost or damaged teeth with artificial materials such as crowns, bridges, and implants.
- iPS cells
- Stem cells made by treating cells of the body so that they return to a state in which they can turn into various types of cells.
- Metal-free restoration
- Treatment that restores missing parts of a tooth with ceramic, resin, or similar materials, without using metal.
- Abutment tooth preparation
- The work of cutting and shaping the tooth that serves as the foundation so that a crown can be placed over it.
NewsLab news
Press release on a titanium surface with a dual micro- and nano-scale structure
Press release on research suggesting a link between oral function and capillaries in the fingertips
A Professor and an Associate Professor received the Society Paper Award of the Japan Prosthodontic Society
A student received an Encouragement Award in the first-round screening of the Student Clinical Skills Competition of the Japan Prosthodontic Society
Press release on research on promoting bone regeneration after tooth extraction through immune cells
ResearchResearch themes
Building on molecular biology, biomaterials science, and related fields, the lab aims to create new regenerative prosthodontic treatments. It also carries out basic and clinical research on all-ceramic crowns and CAD/CAM crowns, and develops prosthodontic devices based on eliminating infection.
*Illustrative imageRegenerating jawbone and teeth with iPS cells
The lab aims to develop regenerative medicine for jawbone and teeth using iPS cells made from gingiva removed during dental treatment. Gingival cells are easy to turn into iPS cells, and the lab is researching methods to guide them into bone-forming cells and to apply them to tooth regeneration.
*Illustrative imageArtificial biomaterials that control cells
The lab develops artificial biomaterials that regulate the behavior of cells and tissues, with the aim of applying them to implant treatment and to regenerative medicine for bone and soft tissue. Using a technology that modifies titanium surfaces at the nanoscale, it examines the bonding with gingival fibers and the effect on the function of skin fibroblasts.
*Illustrative imageLong-term stability of metal-free restorations
The lab conducts both clinical and basic research aimed at the long-term stability, after treatment, of restorations that use no metal, such as all-ceramic and hybrid composite resin restorations. Its work includes prognosis surveys after placement and the design of mechanically stable devices.
*Illustrative imageObjective evaluation of abutment tooth preparation
The lab is developing software that objectively evaluates abutment tooth preparation, the technique of cutting a tooth to fit a crown. Using three-dimensional measurement with a 3D scanner and including damage to adjacent teeth in the evaluation, it aims to standardize and advance dental education.
MembersFaculty
The members of the Molecular and Regenerative Prosthodontics Lab consist of faculty, clinical staff, affiliated faculty, Visiting Professors, Clinical Professors, part-time lecturers, graduate students, visiting researchers, academic researchers, special research students, graduate research students, trainee dentists, secretaries, and others.As of 2026
- ProfessorHiroshi Egusa
- Associate ProfessorKunimichi Niibe
- Assistant ProfessorAkio Harada
- Assistant ProfessorHiroko Okawa
- Assistant ProfessorAtsuhiro Nagasaki
- Assistant ProfessorShun Watanabe
- Assistant ProfessorRyo Gono
- Assistant ProfessorAkane Ozaki
- Assistant ProfessorTakayuki Otake
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Disc with dental implants made with WorkNC” Sescoi CAD/CAM / CC BY-SA 2.0 (cropped)
- Regenerating jawbone and teeth with iPS cells: “A cell culture plate with induced pluripotent stem cells ( )” National Center for Advancing Translational Sciences from Bethesda, MD / Public domain (cropped)
- Artificial biomaterials that control cells: “Titanium screw "volcano" pores with ZnO nanoparticles” Bartosz Woźniak / CC BY 4.0 (cropped)
- Long-term stability of metal-free restorations: “Bridge from dental porcelain” The original uploader was Wagonerj at English Wikipedia. / CC BY-SA 3.0 (cropped)
- Objective evaluation of abutment tooth preparation: “Ceramic crown preparation” EditingDentist / CC BY-SA 4.0 (cropped)
- Related lab (生体再生歯工学分野): “Dental-implant-illustration” Alexmit art / CC BY-SA 4.0 (cropped)
- Related lab (口腔病理学分野): “Hooke Microscope-03000276-FIG-4” 作者不詳 / Public domain (cropped)
- Related lab (歯科医用情報学分野): “Dornbirn-Dental X-ray unit Orthophos SL 3D-02ASD” Asurnipal / CC BY-SA 4.0 (cropped)
- Related lab (顎顔面口腔再建外科学分野): “Implant overdenture model” Coronation Dental Specialty Group[1] / CC BY-SA 3.0 (cropped)
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