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Oral Pathology Lab
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A lab studying oral pathology to understand how tumors and cancers of the teeth and jaws arise.
AboutAbout the lab
Uncovering the true nature of oral and maxillofacial diseases through pathology
The Oral Pathology Lab studies oral pathology, which investigates the true nature of the wide variety of diseases that occur in the oral and maxillofacial region.
The oral and maxillofacial region is made up of many tissues, including both hard and soft tissues, and each site develops its own characteristic lesions.
Besides research, the lab is also in charge of education, including lectures and practical training, and of histopathological diagnosis at the hospital.
Its research focuses mainly on odontogenic tumors, oral cancer, and regeneration and biomaterials.
Key terms
- Odontogenic tumor
- A tumor of the jawbone derived from tooth-forming cells. It is closely related to tooth development and is common in young people.
- Oral cancer
- A malignant tumor arising from the oral mucosa. It commonly occurs on the tongue and gingiva.
- Bioresorbable metallic materials
- Materials that are metals but dissolve inside the body, so they do not need to be removed after use.
ResearchResearch themes
The lab investigates the mechanisms of tumors and cancers in the oral and maxillofacial region, and also explores regenerative methods to restore lost parts of the body. It approaches its research from the perspective of pathology, using a variety of analytical methods.
*Illustrative imageOnset and progression of odontogenic tumors
The lab studies how jaw tumors derived from tooth-forming cells develop and progress. Focusing on molecules that suppress cell death and molecules that regulate tooth development, it is clarifying the effects of molecules involved in immortalization and stem cells.
*Illustrative imageOnset and early detection of oral cancer
The lab studies oral cancer, a malignant tumor arising from the oral mucosa that commonly occurs on the tongue and gingiva. It has shown that smoking- and alcohol-related abnormalities of the p53 tumor suppressor gene and HPV infection are involved in its onset, and is working with many departments on approaches to early detection.
*Illustrative imageRegeneration and biomaterials
To restore parts of the body lost to disease, the lab develops biomaterials and studies regenerative methods. From the perspective of pathology, it studies materials such as bioresorbable metallic materials and ceramic-based materials that replace bone.
MembersFaculty
- ProfessorHiroyuki Kumamoto
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Hooke Microscope-03000276-FIG-4” 作者不詳 / Public domain (cropped)
- Onset and progression of odontogenic tumors: “Teeth, Dentistry, Endodontology, Teeth dental X-rays, Rostov-on-Don, Russia” Vyacheslav Argenberg / CC BY 4.0 (cropped)
- Onset and early detection of oral cancer: “3KMD p53 DNABindingDomian” Richard Wheeler (Zephyris) / CC BY-SA 3.0 (cropped)
- Regeneration and biomaterials: “Humanstemcell” Ryddragyn at English Wikipedia / Public domain (cropped)
- Related lab (歯内歯周治療学分野): “A dental chair in a dentist clinic in North Carolina, United States” Harrison Keely / CC BY 4.0 (cropped)
- Related lab (顎顔面口腔腫瘍外科学分野): “Serum-separation tube” Spiritia / CC BY-SA 4.0 (cropped)
- Related lab (分子・再生歯科補綴学分野): “Disc with dental implants made with WorkNC” Sescoi CAD/CAM / CC BY-SA 2.0 (cropped)
- Related lab (顎口腔組織発生学分野): “Slide under a microscope” Waughd / CC BY-SA 4.0 (cropped)
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