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Oral Biochemistry Lab
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The lab studies coexistence with oral microorganisms to support oral health.
AboutAbout the lab
Understanding oral health through coexistence with microbes
The lab studies the relationship between humans and the community of microorganisms living in the mouth (the oral microbiome).
Using molecular biology methods, anaerobic experimental systems, and omics, the lab investigates how the oral microbiome relates to oral diseases such as dental caries, periodontal disease, and halitosis.
The lab also studies how the metabolic functions of the oral microbiome affect the whole body, as well as the metabolism of cancer cells.
Graduate students have included not only graduates of dental schools but also registered dietitians, pharmacists, and medical laboratory technologists.
Key terms
- Oral microbiome
- The community of microorganisms (such as bacteria) living in the oral cavity. It lives in symbiosis with humans and forms the oral ecosystem.
- Dental caries
- Commonly known as cavities. One of the oral diseases studied by this lab.
- Metabolomics
- A method for comprehensively analyzing the metabolites present in cells and tissues.
ResearchResearch themes
The oral cavity is an ecosystem in which humans and the oral microbiome (microbiota) live together in symbiosis. Using molecular biology methods and omics, the lab studies how the oral microbiome relates to oral diseases such as dental caries, periodontal disease, and halitosis, which occur when the balance of this ecosystem is disrupted.
*Illustrative imageComprehensive analysis of oral microbes
The lab studies the ecosystem formed by the oral microbial community using methods that comprehensively examine genomes, proteins, and metabolites (genomics, proteomics, and metabolomics).
*Illustrative imageOral bacterial metabolism and systemic and oral health
Using anaerobic experimental systems, the lab examines the metabolism of various oral bacteria. It explores how bacterial metabolism relates to systemic and oral health and disease.
*Illustrative imageMechanisms that prevent dental caries and periodontal disease
The lab investigates the mechanisms by which fluoride, sugar alcohols, tea catechins, and similar agents prevent dental caries and periodontal disease.
*Illustrative imageEvaluating the cariogenicity of foods and sweeteners
Using a method called microelectrode pH telemetry, the lab evaluates whether foods and sweeteners are likely to cause dental caries.
MembersFaculty
- ProfessorKen Osaka
- Associate ProfessorJumpei Washio
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Lab technitian looking through the microscope while adjusting coarse knob” Shixart1985 / CC BY 2.0 (cropped)
- Comprehensive analysis of oral microbes: “Revolocity DNA sequencer” Scotted400 / CC BY 4.0 (cropped)
- Oral bacterial metabolism and systemic and oral health: “Anaerobic chamber” Bobjgalindo / CC BY-SA 3.0 (cropped)
- Mechanisms that prevent dental caries and periodontal disease: “Toothbrush, Toothpaste, Dental Care (571741) (cropped)” Steve Buissinne, South Africa / CC0 (cropped)
- Evaluating the cariogenicity of foods and sweeteners: “Würfelzucker” Dietmar Rabich / CC BY-SA 4.0 (cropped)
- Related lab (Endodontology and Periodontology Lab): “A dental chair in a dentist clinic in North Carolina, United States” Harrison Keely / CC BY 4.0 (cropped)
- Related lab (Oral Pathology Lab): “Hooke Microscope-03000276-FIG-4” 作者不詳 / Public domain (cropped)
- Related lab (Developmental Pediatric Dentistry Lab): “Dentist in Mexico attending a child” Miguel Angel Omaña Rojas / CC BY 4.0 (cropped)
- Related lab (International Oral Health Lab): “Toothpaste and toothbrush” James Moore200 / CC BY-SA 4.0 (cropped)
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