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Kidney and Circulatory Therapeutics Creation Lab (Graduate School of Biomedical Engineering)
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The lab explores aging and regeneration through the kidney and circulatory system to create new therapies.
AboutAbout the lab
Aiming to improve whole-body resilience through the kidney and circulatory system
The Kidney and Circulatory Therapeutics Creation Lab focuses on the kidney and the circulatory system, which maintain homeostasis throughout the body, and combines medicine, engineering, and data science in its research.
The kidney regulates body fluid volume, electrolytes, toxins, and more, while the circulatory system controls blood pressure and blood flow.
The circulatory system also carries humoral factors such as hormones, enabling communication between organs (organ crosstalk).
Starting from questions arising in clinical practice, the lab uses disease models based on iPS cells to clarify mechanisms and test candidate therapies, with the aim of developing new treatments.
Key terms
- iPS cells
- Stem cells made from body cells such as skin cells, capable of turning into many different cell types.
- Disease model
- A reproduction of a disease state in an experimental setting. In this lab, disease models are made using iPS cells.
- Organ crosstalk
- The relationship in which organs influence one another through substances such as hormones.
ResearchResearch themes
Focusing on the kidney and the circulatory system, the lab combines medicine, engineering, and data science to improve the body's resistance to disease and its resilience, and to put rejuvenation and regeneration into practice. Starting from problems and questions in clinical practice, the lab builds disease models using iPS cells and engineered human organ models to clarify mechanisms and test candidate therapies.
*Illustrative imageAging of blood vessels and the kidney, and organ crosstalk
The lab studies how blood vessels and the kidney age and how they are connected to organs throughout the body (organ crosstalk). It also works on the analysis of Ageotypes.
*Illustrative imageImproving whole-body resilience and regenerative therapy
The lab works to strengthen the ability of organs throughout the body to resist and recover from disease (resilience), and to develop rejuvenation and regenerative therapies.
*Illustrative imageOrganelles and disease
The lab investigates how the functions of organelles such as mitochondria are related to disease. The findings are applied to the development of treatments.
*Illustrative imageHuman organ models from iPS cells
Using iPS cells and other materials, the lab builds engineered human organ models. These are used to clarify disease mechanisms and test candidate therapies.
MembersFaculty
- ProfessorTakafumi Toyohara
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Laboratory microbiological shaker with cultures-02” real name: Matylda Sęk pl.wiki: Cygaretka commons: Cygaretka / CC BY-SA 3.0 (cropped)
- Aging of blood vessels and the kidney, and organ crosstalk: “Blood Vessel (NIH BioArt 55)” Courtesy of NIAID Ryan Kissinger / Public domain (cropped)
- Improving whole-body resilience and regenerative therapy: “Humanstemcell” Ryddragyn at English Wikipedia / Public domain (cropped)
- Organelles and disease: “Unlabeled Animal Cell” Conrad 7 / CC0 (cropped)
- Human organ models from iPS cells: “Cell Culture in a tiny Petri dish” kaibara87 / CC BY 2.0 (cropped)
- Related lab (Emergent Medicine Lab (SiRIUS Institute of Medicine)): “Barbara McClintock ( ) shown in her laboratory in 1947” Smithsonian Institution/Science Service; Restored by Adam Cuerden / Public domain (cropped)
- Related lab (Diabetes, Metabolism and Endocrinology Lab): “Glucose meters” Christidy at English Wikipedia / Public domain (cropped)
- Related lab (Immunology Lab): “Cell Culture in a tiny Petri dish (cropped)” kaibara87 / CC BY 2.0 (cropped)
- Related lab (Pathophysiology and Humoral Regulation Lab (Biomedical Engineering)): “Microscope 2-photon Bio-Rad pl3” Pleple2000 / CC BY-SA 3.0 (cropped)
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