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Pathophysiology and Humoral Regulation Lab (Biomedical Engineering)
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A lab that aims for healthy longevity by detecting declining mitochondrial function early.
AboutAbout the lab
Healthy longevity through improved mitochondrial function.
Professor Takaaki Abe of the lab serves as the project leader of the "Preemptive Medicine for Mitochondria" project under the Moonshot Research and Development Program (Goal 7).
The project aims to elucidate the regulatory mechanisms of the "mitochondria–gut bacteria axis," in which mitochondria and gut bacteria work together to regulate human health.
It will also develop a noninvasive diagnostic method to examine mitochondrial function, as well as new therapeutic drugs.
The project aims for a society where declining mitochondrial function is detected early and addressed through early intervention and treatment with diet, exercise, and drugs.
Key terms
- Mitochondria
- Organelles in cells that produce energy (ATP). When their function declines, organs throughout the body are affected
- Sarcopenia
- A condition in which muscle mass and strength decline with aging or other causes
- Frailty
- A state in which physical and mental functions weaken with age, making a person more likely to need care
NewsLab news
A research paper showing that a mitochondrial disease drug may be effective against ALS has been published
A lab member received the Best Award at the Biomedical Engineering Summer School 2026
A research paper on reduced tactile stimulation in microgravity and the decline of nerve and muscle function has been published
A research paper on a new aging clock has been published
Professor Takafumi Toyohara received the Audience Award at the Life Science × Acceleration Forum 2026
ResearchResearch themes
It is known that declining mitochondrial function leads to disorders in organs throughout the body, such as hearing loss, sarcopenia, ALS, and Parkinson's disease. The project aims to capture the signals in the body related to mitochondria from every angle, detect functional decline early, and intervene and treat.
*Illustrative imageTherapeutics for mitochondria-related diseases
The aim is to establish therapeutic drugs not only for mitochondrial disease but also for the many diseases in which declining mitochondrial function underlies disease progression, such as hearing loss, sarcopenia, and Parkinson's disease.
*Illustrative imageDeveloping a mitochondrial function sensor
There is currently no simple way to evaluate mitochondrial function. One of the research goals is to develop a mitochondrial function sensor.
*Illustrative imagePersonalized prevention and personalized medicine
The aim is to link sensor data with a database of biomolecular information to establish personalized prevention and personalized medicine, in which rehabilitation, oral care, diet, and drugs for preventing frailty are recommended for each individual.
MembersFaculty
- ProfessorTakaaki Abe
- ProfessorTakafumi Toyohara
- Assistant ProfessorShun Itai
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Microscope 2-photon Bio-Rad pl3” Pleple2000 / CC BY-SA 3.0 (cropped)
- Therapeutics for mitochondria-related diseases: “Medicine Drug Pills on Plate” epSos .de / CC BY 2.0 (cropped)
- Developing a mitochondrial function sensor: “Microscope à fluorescence (Ifremer )” Olivier Dugornay / CC BY 4.0 (cropped)
- Personalized prevention and personalized medicine: “Hospital Pharmacy” User:Mattes / Public domain (cropped)
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