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Diabetes, Metabolism and Endocrinology Lab
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A lab that explores the mechanisms of diabetes and obesity through the connections between organs.
AboutAbout the lab
Examining the whole body, observing the whole body
The Diabetes, Metabolism and Endocrinology Lab carries out research, clinical practice, and education on metabolic diseases such as diabetes, obesity, and atherosclerosis.
Because blood glucose levels and body weight are determined by the sum of the metabolic states of organs throughout the body, the lab investigates how organs coordinate with one another to regulate whole-body metabolism.
The lab's clinical division is the Department of Diabetes and Metabolism at Tohoku University Hospital, and experience in clinical practice is the starting point of its research.
The lab provides support and guidance so that every graduate of the graduate school can obtain qualification as a board-certified diabetologist.
Key terms
- Inter-organ network
- The idea that organs throughout the body, such as adipose tissue and the liver, are connected through neural signals and other means and regulate metabolism together.
- Pancreatic β cells
- Cells in the pancreas that synthesize and secrete insulin.
- Endoplasmic reticulum stress
- A state in which the endoplasmic reticulum, the organelle in cells that folds proteins and performs related tasks, is burdened beyond what it can handle.
NewsLab news
Review article on the control and manipulation of pancreatic β cells by neural signals published in Trends in Endocrinology & Metabolism
An Assistant Professor received the Young Investigator Excellent Presentation Award at the 58th Annual Scientific Meeting of the Japan Atherosclerosis Society
A sixth-year medical student received the Young Investigator Excellent Presentation Award at the 50th Tohoku Regional Meeting of the Japan Endocrine Society
A Lecturer received the Silver Prize of the Tohoku University School of Medicine Scholarship Award
A Professor and a Specially Appointed Professor received the First Prize of the Baelz Prize
ResearchResearch themes
Targeting metabolic diseases such as diabetes, obesity, and atherosclerosis, the lab investigates how organs throughout the body coordinate to maintain metabolic balance. It addresses two subjects at the same time: the mechanisms by which multi-organ organisms live, and the development of treatments for diabetes, obesity, and atherosclerosis.
*Illustrative imageInter-organ Networks and Whole-body Metabolism
The lab found that neural signals from adipose tissue and the liver regulate appetite, basal metabolism, and the proliferation of pancreatic β cells, and proposed the concept of the "inter-organ network." It explores the potential of treatments for obesity and diabetes that make use of this mechanism.
*Illustrative imageAtherosclerosis and Clinical Research
The lab showed that oxidative stress and endoplasmic reticulum stress are involved in the cause of atherosclerosis, and created healthy, long-lived mice by suppressing inflammatory signals in vascular endothelial cells. It is also conducting clinical research to verify these findings in humans.
MembersFaculty
The members of the Diabetes, Metabolism and Endocrinology Lab consist of faculty members (Professor, Project Professor, Specially Appointed Professor, Lecturer, and Assistant Professor), project researchers, clinical staff physicians, graduate students, and resident physicians, joined by faculty members of the Institute for Medical Innovation.As of 2026
- ProfessorHideki Katagiri
- Project ProfessorShinichi Fukushige
- Specially Appointed Professor (Head of Clinical Department)Junta Imai
- Lecturer (Chief of Medical Staff Office)Keizo Kaneko
- LecturerYohei Kawana
- Assistant Professor (Hospital Lecturer, Deputy Head of Medical Staff Office)Kei Takahashi
- Assistant ProfessorSatoko Kurosawa
- Assistant Professor (Ward Chief)Yoichiro Asai
- Assistant Professor (Outpatient Clinic Chief)Misumi Ono
- Assistant ProfessorYuta Tezuka
- Assistant ProfessorHiroto Sugawara
- Assistant ProfessorAkira Endo
- Assistant ProfessorMasato Kohata
- Assistant ProfessorTakahiro Horiuchi
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Glucose meters” Christidy at English Wikipedia / Public domain (cropped)
- Inter-organ Networks and Whole-body Metabolism: “Healthy Deit For A Healthy Well Well and Leave” Ceciliaakan / CC BY-SA 4.0 (cropped)
- Atherosclerosis and Clinical Research: “Blood pressure measurement, Poland” Kris D from Metropolia Silesia, Upper Silesia ( Oberschlesien ) / CC BY-SA 2.0 (cropped)
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- Related lab (Stem Cell Medicine Lab): “Onion cells under the fluorescence microscope 2” Kateryna Kot / CC BY-SA 4.0 (cropped)
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