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Infection Pathophysiology Lab
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A lab that studies the pathophysiology of infection and host defense, aiming to apply its findings to clinical medicine.
AboutAbout the lab
Basic and clinical science united to tackle infectious diseases
The Infection Pathophysiology Lab focuses on basic research on the pathophysiology of infection, host defense, and clinical microbiology.
Since April 2023, the lab has operated by merging the Infection Pathophysiology division of the Health Sciences Program with the Comprehensive Infectious Diseases division of the Medical Science Program, so that basic and clinical researchers work as one.
Its goals are to translate basic research into clinical practice and to apply new findings from clinical research to clinical medicine.
In the professor's greeting, the lab states that it puts effort into training medical researchers who understand clinical infectious diseases and microbiology from both basic and clinical perspectives, as well as healthcare professionals for infectious disease care, where personnel are in short supply.
Key terms
- Infection pathophysiology
- The state of the process in which a pathogen enters the body, causes an infectious disease, and symptoms progress
- Host defense
- The mechanisms by which the body protects itself from pathogens such as bacteria and viruses. Immunity is one of them
- Clinical microbiology
- Microorganisms such as bacteria and viruses found in patients with infectious diseases. The field also covers identifying the cause and testing
NewsLab news
Professor Aoyagi published a review on the outlook of infectious disease research in the Journal of the Japanese Association for Infectious Diseases
Assistant Professor Sato and colleagues announced their research on developing a new vaccine in a press release
ResearchResearch themes
The Infection Pathophysiology division focuses on basic research on the pathophysiology of infection, host defense, and clinical microbiology. It operates together with the Comprehensive Infectious Diseases division, carrying out basic and clinical research with the clinic always in mind, and aims to translate basic research into clinical practice and to apply new findings from clinical research to clinical medicine.
*Illustrative imageNovel antimicrobial peptides against drug-resistant bacteria
To develop treatments for refractory infections caused by drug-resistant bacteria and nontuberculous mycobacteria, the lab aims to develop new peptides with improved stability in the body and higher antimicrobial activity by attaching modifying groups to existing antimicrobial peptides.
*Illustrative imageUnderstanding infection pathophysiology through extracellular vesicles
The lab uses extracellular vesicles, microparticles secreted by cells, to deepen understanding of infection pathophysiology, and is working on a new in vitro method for assessing severity. It has found that during infection, an IL-1-like cytokine is secreted enclosed in extracellular vesicles.
*Illustrative imageSevere infection and macrophage regulation
The lab studies severe infectious conditions such as sepsis and acute respiratory distress syndrome, along with therapeutic strategies for them. It builds new animal models and mainly investigates the regulation of immune cells such as macrophages and monocytes, and of cytokines.
*Illustrative imageA novel vaccine using iron oxide nanoparticles
Aiming for a pneumococcal vaccine that covers many serotypes, the lab developed a vaccine conjugated with iron oxide nanoparticles as an adjuvant. It has confirmed that administering the vaccine to mice through the airway induces mucosal immunity in the lungs.
MembersFaculty
The members of the Infection Pathophysiology division are faculty, master's and undergraduate students, and part-time lecturers. The same members page also lists staff of the Comprehensive Infectious Diseases division and the hospital, senior residents, doctoral students, and visiting professors.As of 2026
- ProfessorTetsuji Aoyagi
- Assistant ProfessorKo Sato
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Clinical Pathology Blood Testing Laboratory in Navi Mumbai, India” Goleisureintl / CC BY 4.0 (cropped)
- Novel antimicrobial peptides against drug-resistant bacteria: “Antibiotic resistant bacteria” Microrao / CC BY-SA 4.0 (cropped)
- Understanding infection pathophysiology through extracellular vesicles: “Brochosome secretion En” Roman Rakitov / CC BY-SA 4.0 (cropped)
- Severe infection and macrophage regulation: “Gram stain of a macrophage with ingested S epidermidis bacteria” Mikael Häggström, M.D. Author info - Reusing images- Conflicts of interest: None Mikael Häggström, M.D. / CC0 (cropped)
- A novel vaccine using iron oxide nanoparticles: “Solo-mrna-vaccine-3” Spencerbdavis / CC BY 4.0 (cropped)
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