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Dermatology Lab
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A lab exploring the mechanisms of skin autoimmunity, stem cells, and hereditary diseases.

AboutAbout the lab
Enjoying dermatology and contributing to the advancement of medicine
The dermatology lab studies how skin diseases arise, with the aim of linking its findings to diagnosis and treatment.
Dermatology is the field that diagnoses and treats lesions that appear on the body surface, including the skin, mucous membranes, nails, and hair.
The lab forms teams around themes such as autoimmune bullous diseases, skin stem cells, cutaneous malignancies, and hereditary skin diseases to advance its research.
Research centers on clinical research that directly benefits clinical practice and basic research that can be applied in the clinic in the future.
Key terms
- Autoimmune bullous diseases
- A general term for diseases in which antibodies that attack components of a person's own skin are produced, causing blisters on the skin.
- Immune tolerance
- The mechanism that keeps the immune system from attacking the body's own components. When it breaks down, autoimmune disease results.
- Epithelial stem cells
- The source cells that continually generate the cells on the surface of the skin. They are also involved in wound healing and aging.
NewsLab news
Assistant Professor Ito received the 10th Takagi Prize
Assistant Professor Ito and colleagues received the FY2025 Outstanding Paper Award from the Faculty of Medicine, Graduate School of Medicine, and School of Medicine (Department of Medicine) at Hokkaido University
A staff physician of the lab received the FY2024 Outstanding Paper Award from the School of Medicine at Hokkaido University
Associate Professor Natsuga received the JSID Award of the Japanese Society for Investigative Dermatology
Professor Ujiie received the Sun Pharma RISING SUN AWARD
ResearchResearch themes
The lab aims to carry out research that can be returned to clinical practice. Teams organized by theme study autoimmune bullous diseases, skin stem cells, cutaneous malignancies, and hereditary skin diseases.
*Illustrative imageSkin immunity and autoimmune bullous diseases
Using aged mice, disease model animals, and patient specimens, the lab investigates how immune tolerance breaks down in the skin. It also studies the roles of T lymphocytes and eosinophils in bullous pemphigoid, and the pathology of drug-induced pemphigoid.
*Illustrative imageSkin stem cells and disease
Focusing on epithelial stem cells of the skin and their behavior, the lab studies inflammatory skin diseases such as psoriasis, skin cancer, wound healing, and aging. It also works to clarify the pathology of rare, intractable diseases such as epidermolysis bullosa and to develop treatments for them.
*Illustrative imageSkin malignancies
The lab studies how skin malignancies such as malignant melanoma, cutaneous squamous cell carcinoma, and lymphoma develop.
*Illustrative imageMechanisms of autoimmune bullous diseases
Using protein functional analysis, cultured cells, and genome editing in mice, the lab investigates how autoimmune bullous diseases arise.
MembersFaculty
The lab's members consist of faculty, staff physicians and residents, graduate students, laboratory assistants, and secretaries. Physicians from the Department of Dermatology at Hokkaido University Hospital also help supervise.As of 2026
- ProfessorHideyuki Ujiie
- Associate ProfessorKen Natsuga
- LecturerMika Watanabe
- Assistant ProfessorTakamasa Ito
- Assistant ProfessorKen Muramatsu
- Assistant ProfessorToshinari Miyauchi
- Assistant ProfessorKeisuke Imafuku
- Assistant ProfessorKodai Miyamoto
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Skin section” Pathologist without beard / CC BY 4.0 (cropped)
- Skin immunity and autoimmune bullous diseases: “Skin Pemphigoid Medium Magnification” Sarahkayb / CC BY-SA 4.0 (cropped)
- Skin stem cells and disease: “HaCaT Cells Phase Contrast” Accuratelibrarian / CC BY-SA 4.0 (cropped)
- Skin malignancies: “Histopathology of a metastatic melanoma to a lymph node” Mikael Häggström, M.D. / CC0 (cropped)
- Mechanisms of autoimmune bullous diseases: “Pemphigus immunofluorescence” Emmanuelm (talk) / CC BY 3.0 (cropped)
- Related lab (Gastroenterology Lab): “Endoscopy” Linda Bartlett / Public domain (cropped)
- Related lab (Plastic Surgery Lab): “Keloid - low mag” Nephron / CC BY-SA 3.0 (cropped)
- Related lab (Integrative Pathology Lab): “Histopathology of severe ulcerative colitis” Mikael Häggström, M.D. / CC0 (cropped)
- Related lab (Ophthalmology Lab): “Fundus photograph-normal retina EDA06” 作者不詳 / Public domain (cropped)
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