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Integrative Pathology Lab
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The lab explores, through pathology, how chronic inflammation leads to tissue regeneration and cancer.
AboutAbout the lab
Experimental and diagnostic pathology: a dual approach
The Integrative Pathology Lab is a pathology lab that approaches the essence of disease through both research and diagnosis.
Its central theme is chronic inflammation, and it studies how inflammation is involved in tissue regeneration, cancer, and aging.
In addition to examining tissue under the microscope, the lab uses newer technologies such as spatial transcriptomics, single-cell analysis, and organoid culture.
Key terms
- Organoid
- A small, organ-like cluster of tissue made by culturing stem cells and other cells in three dimensions
- Spatial transcriptomics
- A method for examining which genes are active at which locations within a tissue, together with positional information
- Tight junction
- An adhesion structure that tightly seals the space between neighboring cells. It is especially abundant between cells of the skin and mucous membranes
NewsLab news
Assistant Professor Iwasaki received the Excellent Teacher Award (Award for Excellence) of the Department of Medicine, School of Medicine for the third consecutive year
A paper by Assistant Professor Iwasaki and colleagues has been accepted by Internal Medicine
A student in the Department of Medicine received the Excellence Award in the Undergraduate Student Poster Presentation at the 115th Annual Meeting of the Japanese Society of Pathology
Paper published on how inflammation is involved in endometrial cancer (press release)
PAGE4 identified as a new therapeutic target in pediatric liver cancer (hepatoblastoma) (press release)
ResearchResearch themes
Chronic inflammation is involved in the onset and progression of disease in many organs. Focusing on the links between inflammation and tissue regeneration and between inflammation and cancer, the lab investigates disease mechanisms using the latest analytical technologies.
*Illustrative imageInflammation and tissue regeneration, inflammation and cancer
Using "inflammatory memory" and "tumor-initiating inflammation" as keywords, the lab investigates how inflammation leads to tissue regeneration and cancer, aiming to develop efficient regeneration methods and new therapies. In addition to organoids, genome editing, and original mouse models, it uses comprehensive analyses.
*Illustrative imageTight junctions that connect cells
The lab studies tight junctions, which hold cells together and prevent substances from leaking through the gaps. It introduces mutations into membrane proteins that form tight junctions, expresses them in cultured cells, and observes changes in the cells and tight junctions.
MembersFaculty
The members of the Integrative Pathology Lab are faculty, technical staff, administrative assistants, professors emeriti and visiting faculty, and doctoral and undergraduate students.As of 2026
- ProfessorKoji Taniguchi
- Assistant ProfessorYukiko Miyatake
- Assistant ProfessorSari Iwasaki
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Histopathology of severe ulcerative colitis” Mikael Häggström, M.D. / CC0 (cropped)
- Inflammation and tissue regeneration, inflammation and cancer: “Organoid (NIH BioArt )” Courtesy of NIAID Ryan Kissinger / Public domain (cropped)
- Tight junctions that connect cells: “Tight junction blowup” The original uploader was DrEricYH at English Wikipedia. / CC BY-SA 2.5 (cropped)
- Related lab (消化器内科学): “Endoscopy” Linda Bartlett / Public domain (cropped)
- Related lab (腫瘍病理学): “Histopathology of prostate adenocarcinoma involving adipose tissue” Mikael Häggström, M.D. / CC0 (cropped)
- Related lab (皮膚科学): “Skin section” Pathologist without beard / CC BY 4.0 (cropped)
- Related lab (スポーツ医科学): “Knee joint 1” John Campbell / CC BY 2.0 (cropped)
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