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Tumor Pathology Lab
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The lab explores the pathology of cancer at the molecular and tissue levels, aiming for diagnosis and treatment that are useful in the clinic.
AboutAbout the lab
Toward translational pathology
The Tumor Pathology Lab studies the mechanisms of disease, centered on cancer, from both pathological tissue and molecular perspectives.
Each member pursues research according to their own interests from among research themes in basic medicine, surgical pathology, and clinical medicine, aiming to contribute to clinical medicine.
The lab also takes part in pathological diagnosis at the university hospital. Career consultations and lab visits are accepted by appointment.
Key terms
- Cancer stem cell
- A small population of cells within a cancer that give rise to the tumor tissue. They resist treatment and cause recurrence
- Hydrogel
- A water-rich, mesh-like gel. Its properties, such as softness, can be adjusted, so it can serve as a base for growing cells
- Glioma
- A tumor arising from glial cells, which support nerve cells in the brain
NewsLab news
A paper from a joint study on SARS-CoV-2 has been accepted by Cell
A student in the Department of Medicine received the Excellence Award in the Undergraduate Student Poster Presentation at the 115th Annual Meeting of the Japanese Society of Pathology
Associate Professor Tsuda received the Hokkaido University Yoshie Katsurada Award
Joint study on SARS-CoV-2 published in Nature Communications
A student in the Department of Medicine received the MBSJ-EMBO Poster Award 2025 at the Annual Meeting of the Molecular Biology Society of Japan
ResearchResearch themes
Centered on cancer, the lab clarifies disease mechanisms by analyzing pathological tissue, with research linked to diagnostic and therapeutic methods. It also conducts joint research with other fields such as materials science and virology.
*Illustrative imageA gel that generates cancer stem cells (the HARP phenomenon)
Cancer stem cells, which cause recurrence, are few in number and change in their properties, so there is currently no method to detect them. Using the HARP phenomenon, in which cancer cells revert to cancer stem cells on a special hydrogel, the lab integrates materials science, biology, and medicine to establish diagnostic and therapeutic methods for cancer stem cells.
*Illustrative imagePathology of COVID-19
The lab has developed a method to evaluate lung tissue from animals infected with SARS-CoV-2 and, in joint research with virologists, examines from pathological tissue how disease develops differently with each variant.
*Illustrative imageAnalysis of brain tumor mechanisms
To apply the findings to the pathological diagnosis of brain tumors, the lab's area of specialty, it studies malignant gliomas and malignant meningiomas from various angles, including stem cells, treatment, and mechanisms of development.
MembersFaculty
The members of the Tumor Pathology Lab are faculty, visiting faculty and visiting researchers, academic researchers, technical staff, technical assistants, administrative assistants, doctoral students, and research students. Physicians from the Diagnostic Pathology and Pathology Divisions of Hokkaido University Hospital also join the lab's staff.As of 2026
- ProfessorShinya Tanaka
- Associate ProfessorMasumi Tsuda
- LecturerZenichi Tanei
- Assistant ProfessorHirokazu Sugino
- Assistant ProfessorYoshitaka Oda
- Assistant ProfessorMarie Kato
- Project Associate ProfessorWang Wang
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Histopathology of prostate adenocarcinoma involving adipose tissue” Mikael Häggström, M.D. / CC0 (cropped)
- A gel that generates cancer stem cells (the HARP phenomenon): “Superabsorber Hydrogel KSG 2917 pK” Petra Klawikowski / CC BY-SA 3.0 (cropped)
- Pathology of COVID-19: “Novel Coronavirus SARS-CoV- )” National Institute of Allergy and Infectious Diseases (NIAID) / CC BY 2.0 (cropped)
- Analysis of brain tumor mechanisms: “Histopathology of glioblastoma, high magnification” Mikael Häggström, M.D. / CC0 (cropped)
- Related lab (細胞生理学): “FPbeachTsien” Nathan Shaner / CC BY-SA 3.0 (cropped)
- Related lab (がん制御学): “Drosophila melanogaster laboratory culture-vial” Masur / CC BY-SA 4.0 (cropped)
- Related lab (神経薬理学): “Diphenhydramine 3D 2aot” Fvasconcellos (talk · contribs) / Public domain (cropped)
- Related lab (免疫学): “Macrophage ( )” NIAID / CC BY 2.0 (cropped)
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