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医化学
Showing the original Japanese · View translation
タンパク質の「ユビキチン化」から、がんや免疫のしくみに迫る研究室。
AboutAbout the lab
タンパク質を壊すしくみから、病気を読み解く。
医化学教室は、
ユビキチン化は、
ユビキチン化を
Key terms
- ユビキチン化
- 小さな
タンパク質ユビキチンを、 ほかの タンパク質に 付ける 反応。 分解の 目印などと して 働く - 翻訳後修飾
- つくられた
タンパク質に、 あとから 化学的な 目印を 付けて 働きを 変える しく み - ユビキチンリガーゼ
- ユビキチンを
付ける 相手の タンパク質を 見分けて、 ユビキチン化を 進める 酵素
NewsLab news
腸内細菌由来の
RNAに よる 大腸がん抑制の しくみの 共同研究が Cell Reports誌に 掲載 がんを
促進する PPM1D酵素の 新たな 分解経路の 論文が J Biomed Sci誌に 掲載 神経・炎症性疾患と
トリプトファン誘導体の 総説が Eur J Cell Biol誌に 掲載
ResearchResearch themes
タンパク質の
*Illustrative imageユビキチン化とタンパク質の分解
細胞の
*Illustrative imageユビキチンリガーゼの多様性
どの
*Illustrative image病気に関わるユビキチン化とリン酸化
がんや
MembersFaculty
医化学教室の
- Professor畠山 鎮次
- Lecturer近藤 豪
- Assistant Professor築山 忠維
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Ubiquitin 1UBQ surface” Thomas Splettstoesser (www.scistyle.com) / CC0 (cropped)
- ユビキチン化と
タンパク質の 分解: “26S proteasome structure” FridoFoe / CC BY-SA 3.0 (cropped) - ユビキチンリガーゼの
多様性: “PDB 1ldj EBI” Jawahar Swaminathan and MSD staff at the European Bioinformatics Institute / Public domain (cropped) - 病気に
関わる ユビキチン化と リン酸化: “Multicolor fluorescence image of living HeLa cells” 8x57is / CC BY-SA 4.0 (cropped) - Related lab (細胞生理学): “FPbeachTsien” Nathan Shaner / CC BY-SA 3.0 (cropped)
- Related lab (神経生理学): “Cortical neurons” Luisa Demarchi, Ilaria Bertocchi, Alessandra Oberto / CC BY-SA 4.0 (cropped)
- Related lab (神経薬理学): “Diphenhydramine 3D 2aot” Fvasconcellos (talk · contribs) / Public domain (cropped)
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