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Cell Physiology Lab
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The lab uses light to observe signals inside living cells and explores the mechanisms of life.
AboutAbout the lab
Understanding life science by seeing it
The Cell Physiology Lab uses fluorescence bioimaging to visualize how signals are transmitted inside cells and how cell membranes and organelles move, studying the mechanisms of life at the cellular level.
The lab captures and analyzes information that changes moment by moment inside cells, in real time and in living cells.
Almost every year, the lab holds a microscopy workshop called the 'Imaging Bootcamp.'
Key terms
- Fluorescence bioimaging
- A method of labeling molecules with fluorescent proteins or dyes and observing their movements in living cells and tissues under a microscope
- Endocytosis
- The process by which a cell engulfs substances from outside with its membrane and takes them in
- FRET
- A phenomenon in which energy transfers between two fluorescent molecules that are close together. It makes it possible to measure molecular binding and shape changes with light
NewsLab news
View More ↗ResearchResearch themes
Using quantitative fluorescence bioimaging, the lab investigates when, where, and to what extent signaling molecules act inside cells. Its research ranges from the basic mechanisms of cells to virus infection and applications in clinical testing.
*Illustrative imageRas Signaling and Cellular Uptake
The lab studies how a complex of Ras and PI3K sends signals not only at the plasma membrane but also on endosomes, and how this regulates endocytosis. It has also shown that PI3K binds to a protein called VDAC2 and links endosomes with mitochondria.
*Illustrative imageHow Influenza Virus Enters Cells
Influenza virus is thought to hijack intracellular signaling systems, such as calcium concentration, to create an environment that makes it easier to enter cells. The lab observes changes in calcium in living cells to investigate how the virus enters.
*Illustrative imageFluorescent Biosensors for Clinical Testing
This research applies FRET biosensors, which measure the activity of molecules inside cells with light, to clinical testing. Using cells from patients with chronic myeloid leukemia, the lab aims to commercialize a technology that tests, cell by cell, which therapeutic drug is effective.
MembersFaculty
The members of the Cell Physiology Lab consist of faculty, visiting professors and visiting researchers, administrative assistants, technical assistants, and doctoral and undergraduate students.
- ProfessorYusuke Ohba
- Associate ProfessorYoichiro Yoichiro
- LecturerTatsuaki Mizutani
- Assistant ProfessorSayaka Kashiwagi
- Project Assistant ProfessorTomoko Kamasaki
- Project Assistant ProfessorAya Satoh
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “FPbeachTsien” Nathan Shaner / CC BY-SA 3.0 (cropped)
- Ras Signaling and Cellular Uptake: “PDB 1he8 EBI” Jawahar Swaminathan and MSD staff at the European Bioinformatics Institute / Public domain (cropped)
- How Influenza Virus Enters Cells: “Influenza A Virus (H1N1)-1” NIH Image Gallery / Public domain (cropped)
- Fluorescent Biosensors for Clinical Testing: “Chronic Myeloid Leukemia smear” Paulo Henrique Orlandi Mourao / CC BY-SA 3.0 (cropped)
- Related lab (医化学): “Ubiquitin 1UBQ surface” Thomas Splettstoesser (www.scistyle.com) / CC0 (cropped)
- Related lab (腫瘍病理学): “Histopathology of prostate adenocarcinoma involving adipose tissue” Mikael Häggström, M.D. / CC0 (cropped)
- Related lab (精神医学): “DTI-sagittal-fibers” Thomas Schultz / CC BY-SA 3.0 (cropped)
- Related lab (形成外科学): “Keloid - low mag” Nephron / CC BY-SA 3.0 (cropped)
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