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Immune Genome Biology Lab
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The lab investigates the mechanisms of immunity and intractable diseases through the functions of B cells.
AboutAbout the lab
Centered on B cells, aiming to identify the causes of intractable diseases and apply the findings to medicine
The Immune Genome Biology Lab, centered on B cells, aims to identify the causes of intractable diseases and apply the findings to medicine.
B cells protect against infection, but they are also deeply involved in the onset and worsening of autoimmune diseases, allergies, and inflammation.
The lab studies B cell differentiation and function at the genome, molecular, cellular, and organismal levels, and extends this work to human B cells.
It also focuses on the breakdown of immune tolerance and immunosenescence, aiming to develop diagnostics and therapies to overcome disease.
Key terms
- B cell
- An immune cell that differentiates in response to antigens, with plasma cells producing antibodies. It is involved in both protection against infection and autoimmune disease
- BCR
- The antigen receptor on the surface of B cells. It recognizes antigens and relays that information into the cell
- Immune tolerance
- A mechanism by which B cells that react to the body's own components are eliminated or inactivated, preventing autoimmune disease
- Immunosenescence
- A phenomenon in which immune function changes with age, leading to more severe infections and weaker vaccine responses
NewsLab news
Received the Best Presentation Award at the Annual Meeting of the Japanese Society for Immunology
Received the Excellent Oral Presentation Award and the Excellent Question Award at the MIB Retreat
Received the Best Presentation Award at the 52nd Annual Meeting of the Japanese Society for Immunology
ResearchResearch themes
The lab clarifies the differentiation and function of B cells at the genome, molecular, cellular, and organismal levels, working to understand the causes and pathology of intractable diseases. Extending this to human B cell research, it aims to develop diagnostics and therapies to overcome autoimmune diseases, allergies, inflammation, cancer, and more.
*Illustrative imageHow B Cells Differentiate
The lab studies the process by which B cells differentiate into germinal center B cells, memory B cells, and plasma cells. By analyzing gene expression, signal transduction, epigenetic regulation, and more, it aims to elucidate the mechanisms that distinguish normal from pathological immune responses.
*Illustrative imageImmune Tolerance and Autoimmune Disease
The lab analyzes, at the molecular, cellular, and organismal levels, how autoreactive B cells, which respond to the body's own components, are controlled and under what conditions they acquire pathogenicity. It focuses on aging, chronic inflammation, interactions with T cells, and more.
*Illustrative imageAging and Decline of Immune Function
By analyzing age-related changes in B cell subsets, the BCR repertoire, intracellular signaling, and metabolic state, the lab aims to clarify the molecular basis of immunosenescence. It also studies B cell mechanisms that link declining immune function to the onset of autoimmunity.
*Illustrative imageBCR Signaling and B Cell Responses
The lab studies the molecular mechanisms that regulate signal transduction of the BCR, the receptor through which B cells recognize antigens, and their physiological and pathological significance. Focusing on differences in signaling among autoreactive B cells, memory B cells, and pathogenic B cells, it explores how B cell fate is determined.
MembersFaculty
The members of the Immune Genome Biology Lab consist of faculty, graduate students, technical staff, joint researchers, and technical officers.As of 2026
- ProfessorYoshihiro Baba
- Associate ProfessorShinya Tanaka
- Assistant ProfessorKeisuke Imabayashi
- Assistant ProfessorKazuhiko Kawata
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Normal Lymph Node” Ed Uthman, MD / CC BY-SA 2.0 (cropped)
- How B Cells Differentiate: “Human B Lymphocyte - NIAID” NIAID / CC BY 2.0 (cropped)
- Immune Tolerance and Autoimmune Disease: “Warm autoimmune hemolytic anemia” E. Uthman, MD / CC BY-SA 2.0 (cropped)
- Aging and Decline of Immune Function: “Elderly man in Rhodes, Greece (black and white)” Martin Hricko / CC BY 3.0 (cropped)
- BCR Signaling and B Cell Responses: “B Cell Receptor (NIH BioArt 617)” Courtesy of NIAID Alexander Stewart / Public domain (cropped)
- Related lab (粘膜防御学): “Cell-1” Mk4716 / CC BY-SA 4.0 (cropped)
- Related lab (クロマチン構造機能研究): “Snf2 ATPase domain in complex with a nucleosome” EMBL-EBI / Public domain (cropped)
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