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Organogenesis and Regeneration Lab
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A lab that explores organ development and regeneration through the workings of stem cells.
AboutAbout the lab
Exploring organ development and regeneration through stem cells
The Organogenesis and Regeneration Lab studies mammalian development and regeneration, focusing on digestive organs such as the liver, intestine, and esophagus.
Through experiments at the levels of genes, cells, tissues, organs, and whole organisms, the lab examines from multiple angles how development proceeds and how regeneration occurs after injury.
By studying the liver, where the existence of stem cells is unclear, alongside the intestine and esophagus, where a stem cell system is essential, the lab seeks to capture the diversity of stem cell systems in digestive organs.
On the lab's website, it is presented under the name "Suzuki Lab."
Key terms
- Stem cell
- A cell that serves as the source of new cells. Their presence is considered essential in the intestine and esophagus
- Foregut endoderm
- An early developmental cell layer from which the liver, intestine, and esophagus all derive
- Direct reprogramming
- A technique in which specific transcription factors are introduced into cells to convert one cell type directly into another
NewsLab news
Prof. Suzuki received the 33rd Kihara Memorial Foundation Academic Award
Research showing that hepatocytes can be converted into intestinal cells published in Nature Communications
ResearchResearch themes
The lab investigates the mechanisms of mammalian development and regeneration, focusing on digestive organs such as the liver, intestine, and esophagus. Using differences in how stem cells function as a clue, it studies lesions that arise from failed liver regeneration and the link between stem cell abnormalities and tumor formation, with the aim of leading to the development of therapies.
*Illustrative imageOrgan-Specific Differences in Stem Cell Function
The liver, intestine, and esophagus all derive from the same foregut endoderm, but after organ formation is complete, the significance of stem cells and progenitor cells differs greatly among them. Stem cells are indispensable in the intestine and esophagus, whereas in the liver the frequency of homeostatic cell division is low, and whether stem cells are needed remains an open question.
*Illustrative imageLiver Regeneration and Stem Cells in the Intestine and Esophagus
In the liver, the lab aims to clarify its complex modes of regeneration and discover hidden stem cell systems, and hopes to connect these findings to elucidating the pathogenesis of liver fibrosis, cirrhosis, and liver cancer that arise from failed liver regeneration, and to developing therapies. In the intestine and esophagus, the lab studies the mechanisms of stem cell self-renewal and cell differentiation, and the link between abnormal stem cell properties and tumor formation.
*Illustrative imageDirect Reprogramming
Direct reprogramming, in which specific transcription factors are introduced into cells to convert them directly into a different cell type, is another of the lab's research themes. The lab has published a paper on generating liver progenitor cells from vascular endothelial cells.
MembersFaculty
The lab's members consist of faculty, doctoral and master's students, technical staff, and administrative assistants.As of 2026
- Professor (Senior Chief Professor)Atsushi Suzuki
- Associate ProfessorKenichi Horisawa
- Associate ProfessorShizuka Miura
- Assistant ProfessorYoshiaki Sakaguchi
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Differentiation of Stem Cells Into Neurons” Axislit / CC BY 4.0 (cropped)
- Organ-Specific Differences in Stem Cell Function: “Neural Stem Cells” Welcome Collection / CC BY-SA 4.0 (cropped)
- Liver Regeneration and Stem Cells in the Intestine and Esophagus: “3D Medical Animation liver parts” https://www.scientificanimations.com / CC BY-SA 4.0 (cropped)
- Direct Reprogramming: “A cell culture plate with induced pluripotent stem cells ( )” National Center for Advancing Translational Sciences from Bethesda, MD / Public domain (cropped)
- Related lab (Stem Cell Medicine Lab): “Liquid nitrogen tank-13” real name: Matylda Sęk pl.wiki: Cygaretka commons: Cygaretka / CC BY-SA 3.0 (cropped)
- Related lab (Skin Regeneration and Aging Lab): “Hair follicle of feline - Microscopic view 1” Juan Carlos Fonseca Mata / CC BY-SA 4.0 (cropped)
- Related lab (Allergy Defense Lab): “Central-nervous-system” Another-anon-artist-234 / CC0 (cropped)
- Related lab (Gene Expression Dynamics Lab): “TranscriptionGraphic PublicDomain” Zulujive / CC0 (cropped)
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