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Skin Regeneration and Aging Lab
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The lab explores the mechanisms of aging and regeneration through skin stem cells.
AboutAbout the lab
Getting to the essence of aging and regeneration through skin stem cells
The Skin Regeneration and Aging Lab uses skin as a model to study the mechanisms of organ regeneration and aging, starting from the behavior of tissue stem cells.
The lab aims to clarify at the molecular level how stem cell heterogeneity is maintained and how it breaks down, and to develop ways to enable organs to keep regenerating over a long period.
The lab is strong in analyses using genetically modified mice, and also incorporates glycan engineering, bioengineering, and omics analysis.
Graduate students belong to the Graduate School of Medical Sciences, and applicants with backgrounds in science or engineering are also welcome.
Key terms
- Tissue stem cell
- A special cell that maintains itself throughout life while producing differentiated cells
- Stem cell heterogeneity
- The coexistence, within the same tissue, of stem cells with different properties, such as how often they divide
- Glycan
- A chain of sugars that modifies proteins, for example on the cell surface. It varies with cell type and state
NewsLab news
Students received the Poster Presentation Award and the Best Discusser Award at the MIB Retreat
A paper showing the relationship between epidermal stem cell aging and fibulin-5 was published in Aging Cell
A paper showing the relationship between the uneven structures of skin and oral mucosa and epidermal stem cells was published in J Invest Dermatol
Prof. Sada received the 22nd JSPS Prize
A paper showing that retinoic acid alters the balance of epidermal stem cells was published in J Invest Dermatol
ResearchResearch themes
When tissue stem cells decline in function or break down, it can lead to cancer, aging, and various diseases. Using mouse and human skin as models, the lab investigates the properties of epidermal stem cells and their regulation, with the aim of controlling aging and advancing regenerative medicine.
*Illustrative imageControlling Skin Aging and Disease
Focusing on epidermal stem cells that divide at different frequencies, the lab studies "stem cell aging," the decline of stem cell function with age. It aims to understand the causes of aging at the cellular and molecular levels and to create new ways to control aging.
*Illustrative imageThree-Dimensional Skin Models
The lab found that epidermal stem cells in human skin are also heterogeneous and are located in distinct regions. By capturing skin structure and stem cell positions in three dimensions, it will build in vitro skin models and establish metrics for evaluation.
*Illustrative imageSkin Aging Seen Through Glycans
Glycans on the cell surface vary with cell type and state. The lab discovered a "glycome shift," in which the glycosylation pattern of membrane proteins changes as epidermal stem cells age. It investigates the roles of glycans and aims to control aging based on glycans.
*Illustrative imageOrgan Development and Regeneration
Using hair follicles and digit tips as models, the lab studies how organs regenerate in mice. It tests whether regeneration and development use the same mechanisms, aiming to establish new methods to regenerate various organs.
MembersFaculty
The members of the Skin Regeneration and Aging Lab consist of faculty, doctoral and master's students, research students, technical staff, and secretaries.As of 2026
- ProfessorAiko Sada
- Associate ProfessorMakoto Takeo
- Assistant ProfessorMizuho Ishikawa
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Hair follicle of feline - Microscopic view 1” Juan Carlos Fonseca Mata / CC BY-SA 4.0 (cropped)
- Controlling Skin Aging and Disease: “Blausen 0811 SkinPores.es” BruceBlaus. When using this image in external sources it can be cited as: Blausen.com staff (2014). "Medical gallery of Blausen Medical 2014". WikiJournal of Medicine 1 (2). DOI:10.15347/wjm/2014.010. ISSN . / CC BY-SA 3.0 (cropped)
- Three-Dimensional Skin Models: “Tissue culture vials nci-vol-2142-300” Unknown photographer/artist / Public domain (cropped)
- Skin Aging Seen Through Glycans: “Skin cancer cells from a mouse show how cells attach at contact points” National Institutes of Health (NIH) / Public domain (cropped)
- Organ Development and Regeneration: “Hair follicle of feline - Microscopic view 2” Juan Carlos Fonseca Mata / CC BY-SA 4.0 (cropped)
- Related lab (幹細胞医学): “Liquid nitrogen tank-13” real name: Matylda Sęk pl.wiki: Cygaretka commons: Cygaretka / CC BY-SA 3.0 (cropped)
- Related lab (器官発生再生学): “Differentiation of Stem Cells Into Neurons” Axislit / CC BY 4.0 (cropped)
- Related lab (遺伝子発現動態学): “TranscriptionGraphic PublicDomain” Zulujive / CC0 (cropped)
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