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Green Chemistry Division Lab
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A research division that links environmentally friendly drug synthesis with drug discovery.
AboutAbout the lab
Combining low-environmental-impact synthesis with drug discovery
The Green Chemistry Division is part of the Green Pharma Institute of the Systems Drug Discovery Research Center at Kyushu University, and studies drug synthesis with low environmental impact.
The institute upholds "Green Pharma," which combines green chemistry (drug synthesis with low environmental impact) with ikuyaku research, which extends already approved drugs to new uses.
Building on synthetic organic chemistry, the fields of Prof. Ohshima and Prof. Hirai develop catalytic synthetic reactions and design and synthesize molecules that could become drug candidates.
The institute brings together people with expertise in synthetic organic chemistry, structural analysis, and clinical pharmacy, and its divisions collaborate on research.
Key terms
- Green chemistry
- An approach to chemistry that makes substances by methods with low environmental impact. Here it is applied to drug synthesis.
- Ikuyaku research
- Research that quickly and safely extends already approved drugs to new diseases and new uses.
- Functional group
- A group of atoms within a molecule that determines how that molecule reacts.
- Chemical biology
- A field that uses molecules made by chemical methods to uncover biological phenomena.
NewsLab news
Prof. Hamase wins the Japan Society for Analytical Chemistry Award
Regioselective deuteration of amides and esters using a catalyst, published in Nature Catalysis
ResearchResearch themes
The Green Pharma Institute combines research on low-environmental-impact drug synthesis with research on drug discovery and ikuyaku, and develops drug candidates and diagnostic markers to overcome serious diseases. In the fields of Prof. Ohshima and Prof. Hirai in the division, research covers the development of environmentally harmonious catalytic reactions and the design and synthesis of bioactive molecules.
*Illustrative imageControlling functional group reactivity with catalysts
Complex molecules such as pharmaceuticals are modified with various functional groups. The lab works on developing reactions in which a catalyst reverses the difference in reactivity between functional groups, and is also building systems that use information science.
*Illustrative imageEnvironmentally harmonious synthesis of natural products
This research aims to synthesize needed bioactive compounds in a practical way using environmentally friendly methods. Using advanced technologies such as flow synthesis, the lab aims for methods that can supply high-value-added compounds even in limited space.
*Illustrative imageGreen Pharma drug discovery research
The lab carries out drug discovery research on anticancer drugs, analgesics, and other drugs as collaborative research. It aims to merge green chemistry and medicinal chemistry and advance to "digital drug discovery" that incorporates machine learning.
*Illustrative imageDevelopment of bioactive molecules and molecular probes
Using synthetic organic chemistry, the lab develops bioactive molecules and molecular probes for chemical biology research. It aims to design and synthesize molecules with unprecedented functions that can serve as lead compounds for new drugs and as tools for biological research.
MembersFaculty
- ProfessorKenji Hamase
- ProfessorTakashi Ohshima
- ProfessorGo Hirai
- ProfessorYasuya Michinaka
- Associate ProfessorRyo Yazaki
- Associate ProfessorHiroyuki Kojima
- Associate ProfessorKenji Hyodo
- Associate ProfessorTakeyuki Akita
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Pharmaceutical Chemistry Lab” 作者不詳 / Public domain (cropped)
- Controlling functional group reactivity with catalysts: “Functional group reactivity ranking” Overworked.raposo / CC0 (cropped)
- Environmentally harmonious synthesis of natural products: “Meshchersky park-2” Dzasohovich / CC BY-SA 4.0 (cropped)
- Green Pharma drug discovery research: “Generic Drug Research ( )” The U.S. Food and Drug Administration / Public domain (cropped)
- Development of bioactive molecules and molecular probes: “Serpentine cords of Mycobacterium tuberculosis complex (MTBC) in a Auramine-Rhodamine fluorescent stained smear of Mycobacterium tuberculosis complex (MTBC) of modified Middlebrook 7H9 Broth” Ajay Kumar Chaurasiya / CC0 (cropped)
- Related lab (Eco-Pharma Division Lab): “Active Transport - Protein Pumps” Christinelmiller / CC BY-SA 4.0 (cropped)
- Related lab (Green Pharma Division Lab): “Medicinal plant , farm Research of KHORRAMAN Pharmaceutical co. - panoramio” Shahram Gandabi / CC BY 3.0 (cropped)
- Related lab (Environmentally Benign Medicinal Chemistry Lab): “Palladium on carbon” Marbletan / CC0 (cropped)
- Related lab (Analytical Chemistry Lab): “D-l-amino acids” Gianluca.molla / CC BY-SA 4.0 (cropped)
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