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Reaction-Driven Drug Discovery Chemistry Lab
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A lab that creates new molecules and reactions and connects them to drug discovery.
AboutAbout the lab
Freely designing and synthesizing molecules to create new reactions and new molecules
The Reaction-Driven Drug Discovery Chemistry Lab is part of a group that works together with the Division of Molecular Synthetic Pharmaceutical Sciences. It works on creating organic molecules that have been difficult to synthesize until now, as well as molecules with new structures, functions, and drug efficacy.
The group develops new molecular transformation reactions and uses them to create next-generation molecules that form the foundation of drug discovery and life sciences.
Going beyond the boundaries of chemistry and pharmaceutical sciences, the lab pursues interdisciplinary research in collaboration with researchers in various fields.
Students can request assignment to the lab as third-year undergraduates or as graduate students.
Key terms
- Protein–protein interactions (PPIs)
- The mechanism by which proteins bind to each other to function. PPIs regulate many biological processes and are targets for drug discovery.
- Deuterated drugs
- Drugs in which hydrogen atoms are replaced with deuterium. Deuterium has the effect of slowing the rate of metabolism.
- Radical reactions
- Reactions that are generally fast and less affected by steric hindrance. They are also well suited to building structures that are difficult to make with anionic or cationic reactions.
NewsLab news
Review on deuteration published in Tetrahedron Chem
Paper published in Organic Letters
Paper published in Nature Catalysis (joint research with AIST and Nagoya Institute of Technology)
Paper published in Nature Communications (joint research with Nagoya Institute of Technology)
Division of Molecular Synthetic Pharmaceutical Sciences and Reaction-Driven Drug Discovery Chemistry Lab launched
ResearchResearch themes
The Reaction-Driven Drug Discovery Chemistry Lab and the Division of Molecular Synthetic Pharmaceutical Sciences pursue drug discovery research through a bottom-up approach based on synthetic organic chemistry. Through original molecules that they design and synthesize, they hope to contribute to creating unprecedented new medicines.
*Illustrative imageDrug Discovery Research Using Original Molecules
Based on its own synthetic methods and molecules, the lab designs and synthesizes medium-sized peptides containing unnatural amino acids and searches for peptides that inhibit protein–protein interactions (PPIs). It also works on developing new synthetic methods for deuterated drugs.
Reaction Development Using Radicals
The lab studies catalytic control of carbon radicals and nitrogen radicals to realize useful molecular transformations. Radical reactions generally have the advantages of being fast and less affected by steric hindrance.
MembersFaculty
Members of the Division of Molecular Synthetic Pharmaceutical Sciences and the Reaction-Driven Drug Discovery Chemistry Lab consist of faculty, technical staff, and undergraduate students.
- LecturerAyumi Osawa
- Associate ProfessorRyo Yazaki
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Fume hood and table of elements, early XX century Gdansk University of Technology” LukaszKatlewa / CC BY 4.0 (cropped)
- Drug Discovery Research Using Original Molecules: “Biological Target Prediction of Bioactive Molecules Based on Minimum Structures Identification” SSamadi15 / CC BY-SA 4.0 (cropped)
- Related lab (Environmentally Benign Medicinal Chemistry Lab): “Palladium on carbon” Marbletan / CC0 (cropped)
- Related lab (Precision Molecular Transformation Chemistry Lab): “Positron Emission Tomography” Christkannada / CC BY-SA 4.0 (cropped)
- Related lab (Drug Molecular Design Lab): “Kandiszucker” Dietmar Rabich / CC BY-SA 4.0 (cropped)
- Related lab (Protein Drug Discovery Lab): “Structural basis for inhibition of TSLP-signaling by Tezepelumab” Kvrstra / CC BY-SA 4.0 (cropped)
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