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Biomolecular Reaction Science Lab
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The lab investigates reactions between biomolecules and links the findings to biotechnology.
AboutAbout the lab
Decoding biomolecular reactions and turning them into technology
The Biomolecular Reaction Science Lab studies the various life phenomena based on interactions (reactions) between biomolecules.
Based on the mechanisms uncovered, it aims to develop technologies that contribute to bio-related industries, especially the development of biopharmaceuticals.
The lab also works to clarify the active-site structure, three-dimensional structure, and catalytic mechanism of enzymes, which are biocatalysts.
Graduate students are admitted through the cooperating course of the Graduate School of Frontier Biosciences and through the Department of Biological Sciences, Graduate School of Science, where the lab's faculty hold concurrent positions within the university.
Key terms
- Odor information DX
- An initiative that aims to turn all odors into digital data using human olfactory receptor sensors
- Coenzyme
- A molecule needed for an enzyme to function. TPQ and CTQ are types that are covalently bound to the enzyme protein
- Bacterial signal transduction system
- The mechanism of signal transmission inside bacteria that is involved in biofilm formation and the expression of virulence. Abbreviated as TCS
ResearchResearch themes
The lab aims to elucidate life phenomena based on interactions (reactions) between biomolecules, develop technologies based on their operating principles, and apply them to areas such as the development of biopharmaceuticals. It is also working to clarify the active-site structure, three-dimensional structure, and catalytic mechanism of enzymes, which are biocatalysts.
*Illustrative imageTurning All Odors into Digital Data
The lab aims to realize 'odor information DX,' which turns all odors into digital data using human olfactory receptor sensors. Professor Kuroda is the principal investigator of this theme.
*Illustrative imageHow the Coenzyme in Amine Oxidase Is Formed
Based on the three-dimensional structure of amine oxidase (AGAO), the lab investigates how the covalently bound coenzyme (the built-in coenzyme TPQ) is formed and how the enzyme's reaction proceeds. Associate Professor Okajima is the principal investigator.
*Illustrative imageHow the Coenzyme in Amine Dehydrogenase Is Formed
Based on the three-dimensional structure of quinohemoprotein amine dehydrogenase (QHNDH), the lab investigates how the covalently bound coenzyme (the built-in coenzyme CTQ) is formed and how the peptide cross-link is formed in the process.
*Illustrative imageAntibacterial Agents Targeting Bacterial Signal Transduction
Based on the three-dimensional structures of bacterial signal transduction systems (two-component systems, TCS) involved in biofilm formation and the expression of virulence, the lab is developing new antibacterial agents that target TCS. Associate Professor Okajima is the principal investigator.
MembersFaculty
The members of the Biomolecular Reaction Science Lab consist of faculty, project faculty, visiting faculty, professors emeritus, doctoral and master's students, and administrative assistants.As of 2023
- ProfessorShun'ichi Kuroda
- Associate ProfessorToshihide Okajima
- Associate ProfessorYoh Wada
- Assistant ProfessorKenji Tatematsu
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “PURH-enzyme 1PKX” Ayacop / Public domain (cropped)
- Turning All Odors into Digital Data: “SPME UCL ISH” ERIO132 / CC BY-SA 4.0 (cropped)
- How the Coenzyme in Amine Oxidase Is Formed: “2c10” Deposition authors: Jakobsson, E., Kleywegt, G.J.; visualization author: User:Astrojan / CC BY-SA 4.0 (cropped)
- How the Coenzyme in Amine Dehydrogenase Is Formed: “Protein Crystal Malic Enzyme” NASA / Public domain (cropped)
- Antibacterial Agents Targeting Bacterial Signal Transduction: “Mixed-culture biofilm” Krzysztof A. Zacharski / CC BY 4.0 (cropped)
- Related lab (Biomolecular Regulation Science Lab): “Antibiotic sensitivity and resistance” Dr Graham Beards / CC BY-SA 4.0 (cropped)
- Related lab (Nagai Lab): “Abnormal transfected HEK 293 cell” Borys Olifirov / CC BY 4.0 (cropped)
- Related lab (Advanced Functional Molecules Lab): “Chlorantraniliprole Ball-N-Stick Avogadro 20200908” Mplanine / CC BY-SA 4.0 (cropped)
- Related lab (Molecular System Creation Chemistry Lab): “Reflexión total” Arturo Francisco Barbero / CC BY-SA 4.0 (cropped)
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