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Molecular System Creation Chemistry Lab
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The lab studies molecular systems that use synthetic organic chemistry to control and visualize biomolecules and cells.
AboutAbout the lab
Obtaining unknown biological information with new molecular systems.
The Molecular System Creation Chemistry Lab (Yamaguchi Lab) uses synthetic organic chemistry to study new molecular systems for obtaining previously unknown biological information.
The lab creates synthetic molecules with desired functions, develops systems that control or visualize biomolecules and cells, and acquires data that no one could obtain before.
The molecular systems it develops serve as platform technologies for solving a wide range of problems, from medical fields such as regenerative medicine, drug discovery, and diagnostics to food and environmental fields such as useful-substance production and biosensors. The lab pursues applied research on them with collaborators in Japan and abroad.
In guiding students, the lab values an approach in which students investigate the background of a problem, form a hypothesis, and test whether it is true through experiments.
Key terms
- regenerative medicine
- Medicine in which cells with desired functions are administered as a drug or as artificial tissue
- light-responsive cell culture surface
- The surface of a culture dish or similar item on which cells attach or detach in response to light
- cell array
- Cells arranged at high density, which allows a large number of cells to be observed at scale under a microscope
ResearchResearch themes
Based on synthetic organic chemistry, the lab creates molecular systems that control, visualize, and produce biomolecules and cells. Using these molecular systems, it takes on a wide range of problems, from medical fields to food and environmental fields.
*Illustrative imageDeveloping light-responsive cell culture surfaces
The lab designs and synthesizes original polymer materials using photochemistry and attaches them to substrates to create culture surfaces on which cells attach or detach instantly in response to light. This leads to technologies for arranging cells freely and for removing them selectively.
*Illustrative imageLight-responsive single-cell array technology
Using light-responsive cell-attachment surfaces, the lab arranges a desired number of cells at each position on a flat substrate and observes the behavior of a vast number of individual cells under a microscope. It is also developing a workflow in which only the desired cells are detached with light and sent on to genetic analysis.
MembersFaculty
The members of the Yamaguchi Lab consist of faculty, visiting professors, project researchers, and doctoral, master's, and undergraduate students.As of 2026
- ProfessorSatoshi Yamaguchi
- Associate ProfessorShinya Yamahira
- Assistant ProfessorHao Zhu
- Project Assistant ProfessorYoko Futaki
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Reflexión total” Arturo Francisco Barbero / CC BY-SA 4.0 (cropped)
- Developing light-responsive cell culture surfaces: “Line of culture flask ( )” Jean-Etienne Minh-Duy Poirrier from USA / CC BY-SA 2.0 (cropped)
- Light-responsive single-cell array technology: “Fluorescence.microscope3” Bioguy10 / CC0 (cropped)
- Related lab (Advanced Functional Molecules Lab): “Chlorantraniliprole Ball-N-Stick Avogadro 20200908” Mplanine / CC BY-SA 4.0 (cropped)
- Related lab (Nagai Lab): “Abnormal transfected HEK 293 cell” Borys Olifirov / CC BY 4.0 (cropped)
- Related lab (Excited Materials Chemistry Lab): “Visible Light Photochemistry Setup” Joanna Yang / CC BY-SA 4.0 (cropped)
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