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Biomolecular Regulation Science Lab
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The lab targets drug efflux pumps to prevent infections caused by multidrug-resistant bacteria.
AboutAbout the lab
Preventing infections caused by multidrug-resistant pathogens
The Biomolecular Regulation Science Lab (Nishino Lab) studies how to prevent infections caused by multidrug-resistant bacteria, which cannot be killed by antibacterial drugs.
Drug efflux pumps in bacteria expel antibacterial drugs and other substances from inside the cell, and are a cause of multidrug resistance.
It has been found that bacterial genomes harbor a surprisingly large number of drug efflux pump genes.
The lab is a research group of the Institute of Scientific and Industrial Research, The University of Osaka, and is also introduced as the Cell Biology (Biological) group of the Graduate School of Pharmaceutical Sciences and Faculty of Pharmaceutical Sciences.
Key terms
- Drug efflux pump
- A mechanism by which bacteria expel antibacterial drugs and other substances from inside the cell. It is a cause of multidrug resistance
- Multidrug-resistant bacteria
- Bacteria that can no longer be killed by antibacterial drugs. They are frequently detected in clinical settings and the environment
ResearchResearch themes
In recent years, multidrug-resistant bacteria that cannot be killed by antibacterial drugs have been frequently detected in clinical settings and the environment, becoming a serious problem worldwide. The lab comprehensively analyzes drug resistance factors latent in bacterial genomes and conducts research to prevent infections caused by multidrug-resistant bacteria.
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MembersFaculty
- ProfessorKunihiko Nishino
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Antibiotic sensitivity and resistance” Dr Graham Beards / CC BY-SA 4.0 (cropped)
- Drug Efflux Pumps and Development of Inhibitors: “Antibiotic sensitivity testing” Bondarev.gal / CC BY 4.0 (cropped)
- Related lab (Biomolecular Reaction Science Lab): “PURH-enzyme 1PKX” Ayacop / Public domain (cropped)
- Related lab (Excited Materials Chemistry Lab): “Visible Light Photochemistry Setup” Joanna Yang / CC BY-SA 4.0 (cropped)
- Related lab (Nagai Lab): “Abnormal transfected HEK 293 cell” Borys Olifirov / CC BY 4.0 (cropped)
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