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Immunochemistry Lab
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The lab investigates infectious diseases and autoimmune diseases through the mechanisms of the immune system.
AboutAbout the lab
Probing the causes of diseases that everyone wonders about
The Immunochemistry Lab studies why the immune system, which evolved to protect the body from infectious diseases, causes abnormalities such as autoimmune diseases.
Focusing on molecules that regulate the function of immune cells, the lab examines how they interact with biomolecules and pathogens to modulate immune responses.
Methods include genetically modified mice, single-cell analysis, RNA-seq, and analysis of receptor-ligand interactions.
It has become clear that neo-self, a new form of autoantigen, plays an important role in the onset of autoimmune diseases.
Key terms
- MHC
- Molecules that display antigen fragments to T cells on the cell surface
- Neo-self
- Autoantigens presented on MHC class II through an unusual pathway. Distinct from those derived from cancer mutations
- Paired receptors
- Receptors on immune cells that come as a pair of an activating type and an inhibitory type
NewsLab news
Professor Hisashi Arase receives the FY2026 Takeda Medical Prize
Assistant Professor Shunsuke Mori receives the 21st Japanese Society for Immunology Research Encouragement Award
Professor Hisashi Arase receives the Mochida Memorial Prize for Academic Achievement
Assistant Professor Shunsuke Mori receives the Japan Medical Association Medical Research Encouragement Award
Paper by a lab researcher on the molecular mechanisms of the high infectivity and tropism of the SARS-CoV-2 Omicron variant published in mBio
ResearchResearch themes
The lab investigates why the immune system, which evolved to protect the body from infectious diseases, causes abnormalities such as autoimmune diseases. Using genetically modified mice and analysis of receptor-ligand interactions, among other methods, it seeks to clarify how molecules on immune cells interact with biomolecules and pathogens.
*Illustrative imageAutoimmune Diseases Caused by Neo-self
The lab considers that CD4 T cells recognize autoantigens presented in an unusual form on MHC class II molecules (neo-self) as foreign, which leads to autoimmune disease. Proliferation of T cells that react to neo-self has also been confirmed in patients with systemic lupus erythematosus.
*Illustrative imagePaired Receptors and Pathogens
Focusing on paired receptors, which consist of an activating type and an inhibitory type, the lab investigates which pathogens, such as viruses, they recognize and how they have evolved together with pathogens.
MembersFaculty
The lab's members consist of faculty, project researchers, doctoral students, technical staff, and secretaries.As of 2026
- ProfessorHisashi Arase
- Associate ProfessorHui Jin
- Assistant ProfessorShunsuke Mori
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Westgate Microscopy t-lymphocytes” Cannons Law Firm, Glasgow, UK / CC BY 4.0 (cropped)
- Autoimmune Diseases Caused by Neo-self: “Antibody Structure” Mamahdi14 / CC BY-SA 4.0 (cropped)
- Paired Receptors and Pathogens: “Human Natural Killer Cell ( )” NIAID / CC BY 2.0 (cropped)
- Related lab (Immunology and Allergy Lab): “T Lymphocyte known as a T cell - 2231” NIAID / CC BY 2.0 (cropped)
- Related lab (Molecular Neuroscience Lab): “Nervous Tissue Spinal Cord Motor Neuron ( )” Berkshire Community College Bioscience Image Library / CC0 (cropped)
- Related lab (Functional Immunogenomics Lab): “Chromatin (NIH BioArt )” Courtesy of NIAID Ryan Kissinger / Public domain (cropped)
- Related lab (Experimental Immunology Lab): “HIV H9 T-cell II” National Institutes of Health (NIH) / Public domain (cropped)
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