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Human Single Cell Immunology Lab
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The lab uses single-cell technologies to explore the diversity of regulatory T cells.
AboutAbout the lab
Seeing immune regulation through individual cells.
The Human Single Cell Immunology Lab, part of the Immunology Group at the Immunology Frontier Research Center, studies the diversity and function of Foxp3-expressing regulatory T cells (Tregs).
Advances in technologies such as mass cytometry and single-cell RNA-seq have revealed substantial heterogeneity within immune cells.
Tregs also take on a variety of functional states, and have been shown to partly mirror the characteristics of effector T cells such as Th1, Th17, and Tfh cells.
Using single-cell technologies such as mass cytometry, the lab examines the diversity of Tregs in settings such as autoimmunity and cancer, and the effects when their function is impaired.
Key terms
- Regulatory T cells (Treg)
- CD4-positive T cells that express Foxp3. They adapt to diverse immune environments and exist in a variety of functional states.
- Mass cytometry
- A single-cell technology also called CyTOF. It allows high-dimensional analysis and is useful for examining the heterogeneity of immune cells.
- Germinal center
- The site where the germinal center reaction of B cells takes place. Tfr downregulate CD25 expression to reach it, and Tregs and Tfr control this reaction through CTLA-4.
ResearchResearch themes
Single-cell technologies have revealed a high degree of heterogeneity among immune cells. Using methods such as mass cytometry, the lab investigates the functional states of regulatory T cells as they adapt to diverse immune environments, and the effects when their function is impaired.
*Illustrative imageFollicular regulatory T cells that suppress antibody production
The lab has studied follicular regulatory T cells (Tfr), which migrate into B cell follicles and suppress antibody production. It showed that Tregs and Tfr control Tfh cell formation and the germinal center reaction through the co-inhibitory receptor CTLA-4, and that a subset of Tfr downregulates CD25 expression in order to reach the germinal center. It has also found Tfr-like cells in human blood.
*Illustrative imageTreg diversity seen through single-cell technologies
Using single-cell technologies such as mass cytometry (CyTOF), the lab investigates the diversity of Tregs, and the effects when Treg function is impaired, in a variety of settings including autoimmunity and cancer.
MembersFaculty
The members of the Human Single Cell Immunology Lab consist of faculty members and researchers.
- ProfessorJames Badger Wing
- Assistant ProfessorLlamas-Covarrubias Mara Anais
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Lymph Node (NIH BioArt 304)” Courtesy of NIAID Ryan Kissinger / Public domain (cropped)
- Follicular regulatory T cells that suppress antibody production: “Intrapulmonary lymph node ( )” Yale Rosen from USA / CC BY-SA 2.0 (cropped)
- Treg diversity seen through single-cell technologies: “Cytomètre de masse” Julien verdier / CC BY-SA 4.0 (cropped)
- Related lab (Experimental Immunology Lab): “HIV H9 T-cell II” National Institutes of Health (NIH) / Public domain (cropped)
- Related lab (Host Defense Lab): “Peritoneal fluid sediment in Wright Staining” Ajay Kumar Chaurasiya / CC BY-SA 4.0 (cropped)
- Related lab (Stem Cell Biology and Developmental Immunology Lab): “Micrograph of a red blood cell with basophilic stippling” Mikael Häggström, M.D. Author info - Reusing images- Conflicts of interest: None Mikael Häggström, M.D.Consent note: Consent from the patient or patient's relatives is regarded as redundant, because of absence of identifiable features (List of HIPAA identifiers) in the media and case information (See also HIPAA case reports guidance). / CC0 (cropped)
- Related lab (Biochemistry and Immunology Lab): “WBCs, apoptosis and echinocytosis in peripheral blood smear, May-Grünwald stain” Bondarev.gal / CC BY 4.0 (cropped)
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