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610 labs · 150 student voices
Susumu Kajiwara, Professor
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The Kajiwara-Orihara Lab studies, at the molecular level, the pathogenic microbes that cause infectious diseases and the mechanisms by which immune diseases arise. The lab investigates the molecular mechanisms involved in the growth, infection, and expression of pathogenicity of pathogenic microbes, as well as the interactions between humans or animals and microbes. In parallel, the lab pursues applied research, such as developing new drugs and preventive methods and developing technologies for producing large amounts of heterologous proteins. The lab also focuses on the circadian clock, with a particular emphasis on research that corrects disruptions of peripheral clocks to restore the balance of immunity.
Tetsuya Kitaguchi, Associate Professor
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The Kitaguchi Lab specializes in bioimaging and analytical chemistry and develops biosensors with original operating principles. By freely combining molecular biology and chemical biology approaches, the lab builds sensors from fluorescent proteins, antibodies, and enzymes. Going beyond visualization and measurement, the lab extends this work to the creation of molecular machines with unique functions. Its goal is to be able to see anything and measure anything.
Naonobu Fujita, Associate Professor
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The Fujita Lab uses Drosophila fruit flies and cultured cells to study how muscle cells are formed and rebuilt. Muscle cells are giant multinucleated cells with highly organized organelles such as T-tubules and the sarcoplasmic reticulum. Their structure and role in muscle contraction are well known, but surprisingly little is understood about the mechanisms that shape them. The lab also works on the physiological functions of autophagy and on the mechanisms that form the slit diaphragm of kidney cells.
Toshinori Fujie, Professor
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The Fujie Lab builds new diagnostic and therapeutic technologies on a foundation of polymer nanofilms. Nanosheets, tens to hundreds of nanometers thick, are exceptionally flexible and adhere directly to living tissue. Key topics are nanobiomaterials, tissue engineering, cell therapy, and wearable and implantable devices. By combining materials, electronic circuits, and living tissue, the lab aims to develop technologies that benefit human health.
Akio Kitao, Professor
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The Kitao Lab uses computer simulation to study how biomolecules carry out their functions. Using large-scale simulation, theory, and structural bioinformatics, it studies proteins, nucleic acids, membranes, and assemblies of biomolecules. Because even complex and diverse life phenomena arise from basic principles such as the laws of physics, they can be understood through physics, chemistry, and mathematics. Drawing on physics, chemistry, computational science, and information science, the lab clarifies life phenomena from the molecular level.
Yasunori Aizawa, Professor
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The Aizawa Lab studies the relationship between the human genome sequence and cell function. Genes (ORFs) account for only 1% of the human genome. The lab re-examines preconceptions about the remaining non-coding regions and explores new causal relationships between genome sequence and cell function (the Genomic Code). The keywords of the research are minimal genomes, genome design, and large-scale genome synthesis.
Yoshitaka Ishii, Professor
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The Ishii Lab uses solid-state NMR spectroscopy to study the mechanisms of life phenomena from molecular structure at the atomic level. A particular focus is determining the structure of amyloid-β protein, which is considered a main cause of Alzheimer's disease. The lab also develops its own new solid-state NMR methods that improve measurement sensitivity and resolution. The lab also collaborates with RIKEN and labs overseas, so people interested in physical chemistry or computer science can also make full use of their strengths.
Kato Akira, Associate Professor
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The Kato Lab studies how diverse animals, mainly fish, adapt to environmental change and maintain homeostasis in the body. The key is the epithelial transport systems in the kidney, digestive tract, and gills. Epithelial cells finely regulate the movement of water, ions, and nutrients in and out of the body, and these basic mechanisms are broadly shared from fish to humans. The lab forms hypotheses from genome information and gene expression data, and tests them with methods such as molecular cell biology and electrophysiology.
Junji Hirota, Professor
0 student voices
The Hirota Lab studies the neural mechanisms of the chemical senses, focusing on olfaction, the sense of smell. It uses mouse genetic approaches that combine genetic engineering and embryo engineering with imaging that makes cells glow. The lab is also developing a new genome engineering technology, the Bacillus subtilis genome (BGM) vector, for handling long DNA. By actually seeing gene activity and neural circuits, the lab approaches the mysteries of olfaction.
Masaaki Wachi, Professor
0 student voices
The Wachi Lab studies bacterial cells to address the question "What is life?" This is because the lab considers the most essential property of life to be replicating itself and multiplying. It investigates why Escherichia coli always divides at the center of the cell and how the bacterial cell cycle proceeds. The lab also searches for new antibiotics and studies how bacteria can be made to produce an ingredient of umami seasoning.
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