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610 labs · 150 student voices
Kengo Sato, Professor
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The Sato Lab studies data-driven bioinformatics using artificial intelligence and machine learning. The lab develops advanced algorithms for analyzing life science and medical data, with the aim of accelerating research in the life sciences. For RNA secondary structure prediction, it has developed methods such as MXfold2, which uses deep learning. The lab also works on drug discovery informatics, which uses computers to find new drug candidates, and on medical AI.
Tomoko Horie, Associate Professor
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Horie Lab studies autophagy, the process by which cells enclose their own contents and degrade them. In particular, the lab focuses on degradation itself, investigating the identity of the degradative enzymes that act in vacuoles and lysosomes. The targets extend beyond proteins to RNA, lipids, sugars, and metabolites. Using yeast, the lab aims to draw a comprehensive atlas of the biomolecules that are degraded, metabolized, and transported.
Ryuji Igarashi, Professor
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Igarashi Lab investigates biological phenomena using nanometer-sized quantum sensors. Using a structure called the NV center in diamond, the lab measures temperature, magnetic fields, and electric fields with high sensitivity. The lab takes on the challenge of quantitatively capturing minute changes inside living cells that have been difficult to measure until now. It also works on building a diagnostic platform that detects early signs of disease from slight abnormalities appearing in blood and other body fluids.
Takuji Yamada, Professor
0 student voices
Yamada Lab analyzes the wide variety of information obtained from biological experiments by computer, in order to discover biological knowledge that is not yet known. This type of research is called bioinformatics. Because a single experiment can now yield an enormous amount of information, the lab develops methods to analyze it quickly and techniques to visualize multidimensional information in an easy-to-read form. With genome information at the core, the lab connects diverse kinds of information and carries out its research in collaboration with bioscience researchers in Japan and abroad.
Yuriko Osakabe, Professor
0 student voices
The Osakabe Lab develops genome editing, a new technology for rewriting genes, along with supporting technologies for using it efficiently. The lab also uses genome editing to modify gene function in a variety of organisms. This work builds on knowledge from genes involved in homeostasis and from the mechanisms by which plants respond to their environment. The lab takes on social problems such as treating intractable diseases and food crises caused by environmental change.
Yoshiaki Masaki, Associate Professor
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The Masaki Lab approaches, from the side of organic chemistry, the challenges that stand in the way of putting nucleic acid therapeutics into actual clinical use. Nucleic acid therapeutics have the potential to treat intractable diseases that cannot be cured today. At the same time, many challenges remain to be solved before they can be applied to treatment. The lab confronts the question of why this cannot yet be done, and advances its research by combining nucleic acid chemistry, physical chemistry, biochemistry, and information science.
Koichiro Uriu, Associate Professor
0 student voices
The Uriu Lab studies biological phenomena using mathematical models and simulations. One pillar is somite formation: the lab investigates how somites, which give rise to vertebrae and ribs, are formed one at a time at a fixed time interval specific to each species. The other pillar is the circadian clock, the internal clock that keeps a period of about 24 hours even in darkness. Through computation, the lab examines how protein concentrations oscillate inside cells and how cells synchronize their rhythms with one another.
Kuroda Kumi, Professor
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The Kuroda Lab studies the brain mechanisms of affiliative sociality, which underpins parent–child relationships and close relationships in families, workplaces, and communities. Using mice, the lab examines the neural circuits that control social behaviors such as parenting, offspring attachment to parents, altruistic behavior, and aggression. In human studies, the lab takes the "transport response," in which babies become calm when they are carried, as a clue and is developing approaches that help stop crying and put babies to sleep. The lab is also conducting machine learning research that predicts an infant's state from data such as heart rate.
Kayo Nozawa, Associate Professor
0 student voices
The Nozawa Lab studies the folded structure of genomic DNA and the mechanisms that determine how genes function. Eukaryotic genomic DNA is folded on a foundation of disc-shaped nucleosomes, and changes in this structure regulate mRNA synthesis. Breakdown of this structure causes diseases such as cancer, lifestyle-related diseases, and psychiatric disorders. Using techniques for "peering into the atomic world," such as X-ray crystallography and cryo-electron microscopy, the lab investigates the causes of these diseases from three-dimensional structures.
Shawn Mcglynn, Associate Professor
0 student voices
The Mcglynn Lab studies how the organization of matter proceeds through the flow of energy. It examines both processes involving living organisms and processes without them, across multiple systems and scales. Its settings include the ways of life of microbes in hot springs, experiments imitating hydrothermal vents, and research tracing the evolutionary history of enzymes. Affiliated with the Earth-Life Science Institute, the lab approaches from chemistry the nature of the energy that triggered the emergence of life.
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