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Kajiwara-Orihara Lab
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The lab studies pathogenic microbes, immunity, and the circadian clock at the molecular level.
AboutAbout the lab
Infectious disease and immunity, through molecular mechanisms
The Kajiwara-Orihara Lab studies, at the molecular level, the pathogenic microbes that cause infectious diseases and the mechanisms by which immune diseases arise.
The lab investigates the molecular mechanisms involved in the growth, infection, and expression of pathogenicity of pathogenic microbes, as well as the interactions between humans or animals and microbes.
In parallel, the lab pursues applied research, such as developing new drugs and preventive methods and developing technologies for producing large amounts of heterologous proteins.
The lab also focuses on the circadian clock, with a particular emphasis on research that corrects disruptions of peripheral clocks to restore the balance of immunity.
Key terms
- Pathogenic microbe
- A microbe, such as a bacterium or fungus, that infects humans or animals and causes disease
- Circadian clock
- A mechanism in the body that keeps a cycle of about one day, including the peripheral clocks found throughout the body
- Drug efflux pump
- A protein that pumps substances such as drugs that have entered a cell back out of the cell
ResearchResearch themes
The lab conducts fundamental research on the molecular mechanisms involved in the growth, infection, and expression of pathogenicity of the pathogenic microbes that cause infectious diseases, and on the molecular mechanisms involved in the onset of immune diseases such as allergies. In parallel, it also pursues applied research, such as developing new drugs and preventive methods and making effective use of microbial functions.
*Illustrative imageLipid synthesis in pathogenic fungi
The lab seeks to elucidate the molecular mechanisms of lipid synthesis that pathogenic fungi, which cause infectious diseases, use when they infect and grow.
*Illustrative imageFinding virulence factors
The lab identifies the virulence factors that allow pathogenic microbes to cause disease and clarifies how they work.
*Illustrative imageSearching for targets of new antifungal drugs
Using genome information, the lab searches for proteins that could serve as targets of novel antifungal drugs.
*Illustrative imageAnalyzing drug efflux pumps
Using yeast and similar organisms, the lab investigates how drug efflux pump proteins from other species function.
MembersFaculty
The members of the Kajiwara-Orihara Lab consist of faculty and doctoral, master's, and undergraduate students.As of 2026
- ProfessorSusumu Kajiwara
- Associate ProfessorKanami OriharaPublications ↗
- Assistant ProfessorXinyue Chen
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Candida albicans 2” Dr Graham Beards / CC BY-SA 3.0 (cropped)
- Lipid synthesis in pathogenic fungi: “Yeast cells and short hyphae in wet mount” Ajay Kumar Chaurasiya / CC0 (cropped)
- Finding virulence factors: “Methicillin-Resistant Staphylococcus Aureus (MRSA) Bacteria colorized scanning electron micrograph - 22” NIAID / CC BY 2.0 (cropped)
- Searching for targets of new antifungal drugs: “Growth inhibition zone of Aspergillus” Atalyssa / CC BY 4.0 (cropped)
- Analyzing drug efflux pumps: “S cerevisiae under DIC microscopy” Masur / Public domain (cropped)
- Related lab (Nobuhiro Nakamura Lab): “Multicolor fluorescence image of a living PC-12 cell” 8x57is / CC BY-SA 4.0 (cropped)
- Related lab (Osakabe Lab): “Arabidopsis thaliana kz07” Krzysztof Ziarnek, Kenraiz / CC BY-SA 4.0 (cropped)
- Related lab (Toda Lab): “Volcano hummingbird (Selasphorus flammula) female in flight 2” Charles J. Sharp / CC BY-SA 4.0 (cropped)
- Related lab (Kato Lab): “Takifugu poecilonotus by DaijuAzuma” Daiju Azuma / CC BY-SA 4.0 (cropped)
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