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Uriu Lab
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A lab that uses mathematical models to unravel the rhythms of living things.
AboutAbout the lab
Capturing the rhythms of living things in equations
The Uriu Lab studies biological phenomena using mathematical models and simulations.
One pillar is somite formation: the lab investigates how somites, which give rise to vertebrae and ribs, are formed one at a time at a fixed time interval specific to each species.
The other pillar is the circadian clock, the internal clock that keeps a period of about 24 hours even in darkness.
Through computation, the lab examines how protein concentrations oscillate inside cells and how cells synchronize their rhythms with one another.
Key terms
- Mathematical model
- A method of expressing the mechanism of a phenomenon in equations and verifying it by running calculations
- Segmentation clock
- Oscillations of protein concentration inside cells that set the time period at which somites are formed
- Circadian clock
- A clock that organisms have inside the body, which keeps a rhythm of about 24 hours even in darkness
NewsLab news
View More ↗ResearchResearch themes
The lab studies biological phenomena using mathematical models and simulations. Its main subjects are two kinds of rhythms: the segmentation clock, which governs somite formation in vertebrates, and the circadian clock, with which organisms keep a rhythm of about 24 hours.
*Illustrative imageCell movement and the segmentation clock
The segmentation clock that forms somites works as cells synchronize their rhythms with one another. Reproducing cell movement on a computer showed that the more the cells move, the more easily synchronization occurs.
*Illustrative imageResynchronization of the segmentation clock
In zebrafish embryos, the segmentation clock was once desynchronized, and the process of resynchronization was analyzed using mathematical models and imaging. The lab showed that the way synchronization occurs changes depending on how the tissue deforms.
*Illustrative imageDivision of roles between Per1 and Per2
Light information enters through the clock genes Per1 and Per2. The expression rhythms of the two are offset by about 4 hours, and the lab used a mathematical model to show that this offset gives rise to a division of roles in which Per1 advances the clock and Per2 delays it.
*Illustrative imageThe dead zone of the body clock
There is a time window during the day when exposure to light does not shift the phase of the circadian clock, known as the dead zone. The lab showed theoretically that a dead zone arises when the reaction that produces the repressor in the negative feedback loop becomes saturated.
MembersFaculty
- Associate ProfessorKoichiro UriuPublications ↗
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Brachydanio rerio” Marrabbio2 / Public domain (cropped)
- Cell movement and the segmentation clock: “CSIRO ScienceImage 7598 larval zebra” CSIRO / CC BY 3.0 (cropped)
- Resynchronization of the segmentation clock: “Zebrafish-Embryo-dark-field” Giudicelli F, Özbudak EM, Wright GJ, Lewis J / CC BY 2.5 (cropped)
- Division of roles between Per1 and Per2: “Sunrise at viru bog” Abrget47j / CC BY-SA 3.0 (cropped)
- The dead zone of the body clock: “Circadian clock of mammals” Nitramus / CC BY-SA 3.0 (cropped)
- Related lab (Tanaka Lab): “Embryo in chicken egg (Gallus domesticus) after 72 hours of incubation” Monika Tumialis (Eksnazja) / CC BY 4.0 (cropped)
- Related lab (Kajiwara-Orihara Lab): “Candida albicans 2” Dr Graham Beards / CC BY-SA 3.0 (cropped)
- Related lab (Sawada Lab): “Bacteriophage T5 2024 ps” Dr. Victor Padilla-Sanchez, PhD / CC BY-SA 4.0 (cropped)
- Related lab (Sekine Lab): “Multicolor fluorescence image of living HeLa cells” 8x57is / CC BY-SA 4.0 (cropped)
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