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Precision Synthetic Chemistry Lab
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The lab develops new reactions powered by transition metals to make building blocks for medicines.
AboutAbout the lab
Creating new reactions through organometallic chemistry
The Precision Synthetic Chemistry Lab studies the development of new chemical reactions based on organometallic chemistry.
Using metals such as nickel and palladium, the lab creates reactions useful for synthesizing drugs and natural products.
The reactions it discovers are applied to the synthesis of biologically active compounds and pharmaceutical precursors.
The lab also focuses on developing environmentally friendly organic synthesis reactions and catalytic processes.
Key terms
- Organometallic chemistry
- A field of chemistry that deals with the properties and reactions of compounds containing metal–carbon bonds
- Chirality (asymmetry)
- A property of molecules that cannot be superimposed on their mirror image, like a right hand and a left hand. In drugs, sometimes only one form is effective
- Enolate
- A highly reactive form of molecule that is often used to join carbon atoms together in organic synthesis
NewsLab news
Paper by master's students accepted in Synlett
Paper by master's students accepted in Organometallics
A master's student received the Student Excellent Presentation Award at the 153rd Meeting of the Hokkaido Branch of the Pharmaceutical Society of Japan
Doctoral and master's students received the Student Excellent Presentation Award at the 146th Annual Meeting of the Pharmaceutical Society of Japan
Paper by an alumnus accepted in ACS Catalysis
ResearchResearch themes
The lab centers on developing reactions grounded in organometallic chemistry and actively applies the results to organic synthesis. It aims to develop new reactions that can be used to synthesize biologically active compounds and functional materials.
*Illustrative imageSynthesizing carboxylic acids from carbon dioxide
The lab develops methods that use unreactive carbon dioxide as a carbon source to synthesize carboxylic acids with metals such as nickel, cobalt, and palladium. It has succeeded in synthesizing optically active amino acids, biologically active natural products, and pharmaceutical precursors.
*Illustrative imageBuilding complex skeletons through asymmetric cyclization
Many natural products have structures with stereogenic carbon centers on a ring. The lab has developed asymmetric cyclization reactions that hinge on cyclic intermediates containing rhodium, and it studies methods for assembling complex skeletons in a single step.
*Illustrative imageEnolate formation with palladium
The lab has found a new way to generate enolates, one of the most important reaction partners in organic synthesis, using palladium. It is exploring their reactivity with the aim of applying them to organic synthesis.
MembersFaculty
The members of the Precision Synthetic Chemistry Lab consist of faculty, doctoral, master's, and undergraduate students.As of 2026
- ProfessorYoshihiro Sato
- Associate ProfessorYoshihiro Oonishi
- Assistant ProfessorKazuhiro Morisaki
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “CSIRO ScienceImage 10606 High vacuum apparatus” division, CSIRO / CC BY 3.0 (cropped)
- Synthesizing carboxylic acids from carbon dioxide: “Carbon-dioxide-3D-balls” Benjah-bmm27 / Public domain (cropped)
- Building complex skeletons through asymmetric cyclization: “Rhodium powder pressed melted” Alchemist-hp (talk) www.pse-mendelejew.de derivative work: Purpy Pupple (talk) / CC BY-SA 3.0 de (cropped)
- Enolate formation with palladium: “Palladium crystals” Hi-Res Images of Chemical Elements / CC BY 3.0 (cropped)
- Related lab (Natural Product Synthesis Lab): “Rotationsverdampfer ohne Vakuumpumpe” HaJo88 / CC BY-SA 4.0 (cropped)
- Related lab (Molecular and Cellular Pharmaceutical Sciences Lab): “1 msc DAPI+ThR001 a” OlgaMaslova / CC BY-SA 4.0 (cropped)
- Related lab (Uraguchi Lab): “Working in the Process Chemistry Lab ( )” National Center for Advancing Translational Sciences from Bethesda, MD / Public domain (cropped)
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