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Health Chemistry Lab
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The lab explores the mechanisms of mucosal immunity by studying the epithelial cells that cover the surfaces of the intestine and airways.
AboutAbout the lab
Uncovering how mucosal epithelial cells function and are regulated
The Health Chemistry Lab studies the functions of the epithelial cells that cover mucosal surfaces such as those of the intestine and airways.
The mucosal epithelium is a barrier that keeps out foreign substances and bacteria. It is also a gateway that senses information from the outside and selectively takes in the substances the body needs.
Among these cells, the lab focuses on M cells, which take up foreign substances in the intestine and activate the immune system.
Using mouse and human organoids, the lab investigates how M cells form and what roles they play, with the aim of developing mucosal vaccines.
Key terms
- M cells
- Specialized epithelial cells in the intestinal mucosa. They take up foreign substances and bacteria in the intestine and pass them on to immune cells.
- Organoids
- Small tissues made by culturing stem cells in three dimensions, which partially mimic the structure and function of an organ.
- Mucosal vaccines
- Vaccines given through the mouth or nose that aim to prevent infection by activating immunity in the mucosa.
ResearchResearch themes
The lab aims to clarify the function of each cell type that forms the mucosal epithelium of the intestine and respiratory tract, and to connect these findings to applications. In particular, it studies the differentiation and function of M cells, which take up antigens in the lumen and activate mucosal immunity.
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MembersFaculty
- ProfessorShunsuke Kimura
- Assistant ProfessorKazuaki Nakata
- Assistant ProfessorShinya Hiraishi
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Ileum biopsy with lymphoid tissue, intermed. mag” CoRus13 / CC BY-SA 4.0 (cropped)
- M Cell Differentiation and Mucosal Immunity: “Cross-section histology of small intestinal villi of the terminal ileum” Mikael Häggström, M.D. / CC0 (cropped)
- Related lab (遺伝子病制御研究所 病態研究部門 感染腫瘍学分野): “Ulcer-causing Bacterium (H.Pylori) Crossing Mucus Layer of Stomach” Illustration Credit: Zina Deretsky, National Science Foundation / Public domain (cropped)
- Related lab (薬剤分子設計学研究室): “Generic Drug Research ( )” The U.S. Food and Drug Administration / Public domain (cropped)
- Related lab (生体分析化学研究室): “Molecubes SPECT uCT and PET” Adville / CC BY-SA 4.0 (cropped)
- Related lab (RNA生物学研究室): “FISH 13 21” Gregor1976 / Public domain (cropped)
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