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Oral and Maxillofacial Functional Therapeutics Lab
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A lab that treats disorders of oral function: speaking, eating, and breathing.
AboutAbout the lab
Improving oral functions for speaking, eating, and breathing
The Oral and Maxillofacial Functional Therapeutics Lab addresses disorders of the oral functions of speaking, eating, and breathing through both treatment and clinical education and research.
Its targets include speech disorders, dysphagia (eating and swallowing disorders), and sleep apnea, as well as xerostomia (dry mouth) and malnutrition caused by oral dysfunction.
Its research includes developing endoscopic evaluation methods, analyzing swallowing dynamics with videofluoroscopic swallowing studies, and analyzing the mechanisms of salivary gland regeneration.
Key terms
- Dysphagia (eating and swallowing disorders)
- A condition in which some part of the sequence of taking food into the mouth and sending it to the stomach is impaired, making it hard to swallow smoothly.
- Oral appliance
- A device placed in the mouth that is used to treat sleep apnea syndrome. Also called an OA.
- Xerostomia
- Also called dry mouth. It refers not only to reduced saliva secretion but also to the symptom of feeling that the mouth is dry.
ResearchResearch themes
The lab provides treatment and conducts clinical education and research on disorders of the oral functions of speaking, eating, and breathing. Its research covers speech disorders, dysphagia, sleep apnea, xerostomia, and nutritional dentistry, which deals with nutritional status.
*Illustrative imageTreating speech disorders, including cleft palate
The lab deals with articulation disorders, which affect the production of speech sounds in the mouth, and has long studied velopharyngeal closure function from a physiological perspective in speech therapy for cleft palate. It now also examines postoperative outcomes and conducts basic genetic research aimed at controlling the development of cleft palate from the embryonic stage.
*Illustrative imageAssessing swallowing and preventing functional decline
As a way to assess dysphagia, the lab is developing a method that uses an endoscope to examine the ability to form a food bolus. It also analyzes swallowing dynamics using videofluoroscopic swallowing studies and, jointly with Osaka Electro-Communication University, studies the prevention of disuse-related decline in swallowing function.
*Illustrative imageIndications for oral appliance therapy for sleep apnea
It is unclear which cases are suited to oral appliances (OA) for sleep apnea syndrome, so the lab studies how to improve the diagnosis of suitability by observing changes in the airway with an endoscope. Together with the National Cerebral and Cardiovascular Center, the lab has also begun research on determining treatment effects noninvasively through exhaled gas analysis.
*Illustrative imageResearch aimed at regenerating salivary glands
There is no fundamental treatment for xerostomia, in which reduced saliva causes a dry mouth, and new treatments such as tissue regeneration therapy are awaited. Together with the US NIH, the lab continues research analyzing the molecular mechanisms involved in salivary gland regeneration.
MembersFaculty
- ProfessorTakayoshi Sakai
- Associate ProfessorKanji Nohara
- Assistant ProfessorNobukazu Tanaka
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Team Mildenhall Dental Clinic- Bright smiles lead to mission success (4967541)” U.S. Air Force photo by Airman 1st Class Brandon Esau / Public domain (cropped)
- Treating speech disorders, including cleft palate: “Cleft palate alveolus panorex xray” Coronation Dental Specialty Group / CC BY-SA 4.0 (cropped)
- Assessing swallowing and preventing functional decline: “Graded soft semi-solid food” Ashashyou / CC BY-SA 3.0 (cropped)
- Indications for oral appliance therapy for sleep apnea: “Mandibular advancement splint (human, not inserted)” Mattes / CC BY-SA 2.0 (cropped)
- Research aimed at regenerating salivary glands: “Glands - Salivary glands -- Smart-Servier” Laboratoires Servier / CC BY-SA 3.0 (cropped)
- Related lab (Oral Physiology Lab): “Dental tool work DVIDS264901” Petty Officer 3rd Class Jake Berenguer / Public domain (cropped)
- Related lab (Special Needs Dentistry Lab): “Child receives dental care in a clinic with a smiling dentist” Shixart1985 / CC BY 2.0 (cropped)
- Related lab (Preventive Dentistry Lab): “Stock Images Electric Toothbrush” Electric Teeth / CC BY 2.0 (cropped)
- Related lab (Oral and Maxillofacial Surgery Lab): “Dental instruments by Roboz Tech Surgical” RobozTech / CC BY-SA 4.0 (cropped)
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