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Obesity and Adipose Tissue Pathophysiology Lab
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The lab investigates the pathology of adipocytes to uncover the mechanisms of metabolic syndrome.
AboutAbout the lab
Understanding lifestyle-related diseases through the function of adipocytes
The lab studies what happens in the adipose tissue and adipocytes of people with obesity, aiming to uncover the mechanisms by which metabolic syndrome develops.
Adipocytes store energy when there is a surplus and release it when there is a shortage, which keeps the body's condition stable.
In modern Japan, however, increased calorie intake and lack of exercise cause surplus energy to keep flowing into adipocytes, which is described as leading to conditions such as diabetes and dyslipidemia.
Centered on pathological analysis of obese adipose tissue and functional analysis of adipocytokines, the lab aims to overcome lifestyle-related diseases.
Key terms
- Adipocytokines
- A general term for factors produced by adipocytes. They include SDF-1 and the beneficial adiponectin, among others.
- Insulin resistance
- A state in which insulin becomes less effective. In adipocytes, glucose uptake decreases.
- Treg (regulatory T cell)
- T cells that suppress effector T cells and regulate immune responses. They are abundant in adipose tissue.
ResearchResearch themes
Adipocytes store energy when there is a surplus and release it when there is a shortage, which keeps the body's condition stable. The lab investigates the pathology of obese adipose tissue and the functions of adipocytokines produced by adipocytes, aiming to clarify the mechanisms by which metabolic syndrome develops.
*Illustrative imageOxidative stress in adipose tissue
In obese adipose tissue, enzymes that produce reactive oxygen species increase and the activity of antioxidant enzymes declines, resulting in a state of oxidative stress. The lab studies how this adipose tissue oxidative stress causes dysregulation of adipocytokines and insulin resistance.
*Illustrative imageHypoxia in adipose tissue
In obese adipose tissue, adipocytes enlarge but the growth of blood vessels cannot keep up, so blood flow decreases and the tissue becomes hypoxic. The lab studies how dysregulation of adipocytokines and insulin resistance occur in hypoxic adipocytes.
*Illustrative imageTregs in adipose tissue
Tregs are abundant in adipose tissue but decrease in obesity. The lab studies the involvement of adipose tissue macrophages in the differentiation and proliferation of Tregs, and how metabolites of EPA induce this.
*Illustrative imageSDF-1 and insulin resistance
SDF-1, which is produced by adipocytes, suppresses the insulin sensitivity of the adipocytes themselves. The lab has shown that SDF-1 increases during fasting and in obesity, which reduces glucose uptake and causes insulin resistance.
MembersFaculty
- Professor, Endowed ChairMichio Otsuki
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Connective Tissue Adipose ( )” Berkshire Community College Bioscience Image Library / CC0 (cropped)
- Oxidative stress in adipose tissue: “Adipose tissue” Yuki T. Okamura / CC0 (cropped)
- Hypoxia in adipose tissue: “Fat cells (red) and blood vessels (green) ( )” NIH Image Gallery from Bethesda, Maryland, USA / Public domain (cropped)
- Tregs in adipose tissue: “T Regulatory Cells ( )” NIAID / CC BY 2.0 (cropped)
- SDF-1 and insulin resistance: “Blausen 0012 AdiposeTissue” BruceBlaus. When using this image in external sources it can be cited as: Blausen.com staff (2014). "Medical gallery of Blausen Medical 2014". WikiJournal of Medicine 1 (2). DOI:10.15347/wjm/2014.010. ISSN . / CC BY 3.0 (cropped)
- Related lab (Metabolism and Vascular Medicine Lab): “Histopathology of coronary artery atherosclerosis, original” Mikael Häggström, M.D. Author info - Reusing images- Conflicts of interest: None Mikael Häggström, M.D.Consent note: Consent from the patient or patient's relatives is regarded as redundant, because of absence of identifiable features (List of HIPAA identifiers) in the media and case information (See also HIPAA case reports guidance). / CC0 (cropped)
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