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Clinical Gene Therapy Lab
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A lab exploring new diagnosis and treatment for dementia and for heart and vascular diseases.
AboutAbout the lab
Translational research on dementia that links basic science and clinical practice.
The Clinical Gene Therapy Lab carries out research in several groups, including a dementia group and a cardiovascular group.
The dementia group studies tau protein in Alzheimer's disease and develops methods for assessing cognitive function using eye gaze.
The cardiovascular group targets heart failure, vascular diseases, aging, stem cells, and cancer, aiming to develop new therapeutic drugs and other treatments that are useful in clinical practice.
The lab also has a health and developmental medicine group, an immunity, cerebrovascular, and neurology group, and a collaborative research group.
Key terms
- Tau protein
- A protein that accumulates in the brains of people with Alzheimer's disease and is considered one of the substances that cause damage to nerve cells
- Tau propagation hypothesis
- A hypothesis that explains how, in Alzheimer's disease, aggregates of phosphorylated tau appear progressively along specific brain regions
- Eye tracking
- A technology that records where a person is looking. This lab uses it in an assessment method that measures cognitive function through gaze analysis
NewsLab news
A paper by Prof. Takeda has been accepted by Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
Assistant Professor Yuki Ito won the YIA Excellence Award at the 16th Annual Meeting of the Japanese Society of Cerebrovascular Disease and Dementia
Prof. Takeda received the Special Prize at the 10th Bio Industry Award
The eye-tracking cognitive function assessment app won the top award in the Medical ICT category of the MM Research Institute Award 2026
An original paper by Assistant Professor Yuki Ito has been accepted by Vas-Cog Journal
ResearchResearch themes
The Clinical Gene Therapy Lab has groups for dementia, cardiovascular disease, health and developmental medicine, immunity/cerebrovascular/neurology, and collaborative research. The dementia group introduced here pursues a wide range of research: elucidating the molecular pathology of Alzheimer's disease and drug discovery, clinical research such as biomarker development, and field studies on problems in dementia nursing and caregiving.
*Illustrative imagePathology and Treatment of Alzheimer's Disease
The group focuses on tau protein, which accumulates in the brains of people with Alzheimer's disease. As research related to the tau propagation hypothesis, it has identified the tau molecular species involved in propagation from autopsied patient brains, and it is also developing a therapeutic vaccine that suppresses tau propagation.
*Illustrative imageNew Drug Discovery Targets for Dementia
Focusing mainly on patients with early-stage dementia, the group investigates the pathology that occurs in the brain before and after onset. It collects high-quality biological samples together with accurate clinical information, derives new hypotheses about the pathology through transcriptome analysis (RNA-Seq) and other methods, and pursues research that leads to drug discovery.
*Illustrative imageAssessing Cognitive Function with Digital Technology
The group is developing an eye-tracking assessment method that records the gaze of a subject watching a task video of about three minutes and measures cognitive function from the gaze positions. It is also developing a method for assessing frailty using AI-based image analysis.
*Illustrative imageLinks Between Dementia and Lifestyle-Related Diseases
Lifestyle-related diseases such as diabetes and hypertension have been reported as risk factors for dementia. The group developed its own model mice with both diabetes and Alzheimer's disease, and has elucidated the mechanisms by which the two diseases influence each other's pathology.
MembersFaculty
The Clinical Gene Therapy Lab's members include faculty, project researchers, doctoral, master's, and undergraduate students, vocational school students, and research assistants.As of 2026
- Professor, Endowed ChairRyuichi Morishita
- Assistant Professor, Endowed ChairYuki Ito
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “AAV Gene Therapy” George Church / CC BY-SA 3.0 (cropped)
- Pathology and Treatment of Alzheimer's Disease: “Beta-Amyloid Plaques and Tau in the Brain ( )” NIH Image Gallery from Bethesda, Maryland, USA / Public domain (cropped)
- New Drug Discovery Targets for Dementia: “Deep Brain Stimulation (DBS) of Nucleus Basalis of Meynert” Zhang Q, Kim Y-C and Narayanan NS / CC BY 4.0 (cropped)
- Assessing Cognitive Function with Digital Technology: “Eye-tracking setup” Naomi Nota / CC BY-SA 2.0 (cropped)
- Links Between Dementia and Lifestyle-Related Diseases: “Fcvm- -g0001” Mossanen Parsi M, Duval C, Ariëns RAS. / CC BY 4.0 (cropped)
- Related lab (Drug Discovery Neuroscience Lab): “Drug discovery cycle 2” Boghog / CC BY-SA 4.0 (cropped)
- Related lab (Health and Developmental Medicine Lab): “Japanese female scientist wearing plastic gloves holding syringe and vial, researching a coronavirus vaccine ( )” Japanexperterna.se from Japan / CC BY 2.0 (cropped)
- Related lab (High-Precision Image-Guided Puncture Therapy Lab): “Interventional radiology” Elena Escalante Porrua / CC BY-SA 4.0 (cropped)
- Related lab (Gene and Stem Cell Regenerative Therapeutics Lab): “AA01946a” SozvezdieL / CC BY 4.0 (cropped)
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