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Dermatology Lab
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A lab that unravels intractable skin diseases from an immunological perspective.
AboutAbout the lab
Understanding intractable skin diseases through immunology.
Under Professor Manabu Fujimoto, the Dermatology Lab works to elucidate the pathology of, and establish treatments for, connective tissue diseases and immune disorders, including scleroderma and dermatomyositis.
Research is divided among faculty members and investigates autoantibodies in connective tissue diseases, the functions of B cells, T cells in the skin, and the relationship between skin bacteria and inflammation.
The lab is an organization in which the Department of Dermatology of the Osaka University Faculty of Medicine and its affiliated hospitals work together in clinical practice, research, and education in dermatology.
The lab holds information sessions and visits for the department for medical students and junior residents.
Key terms
- Connective tissue disease (collagen disease)
- Intractable diseases of unknown cause, including scleroderma and dermatomyositis. B cells and T cells are thought to be involved
- B cell
- A type of lymphocyte responsible for adaptive immunity. It differentiates into plasma cells that produce antibodies
- Resident memory T cell
- A T cell that, after migrating to peripheral tissue, does not recirculate and stays in the tissue
- Quorum sensing
- A mechanism by which bacteria sense their own population density
NewsLab news
View More ↗ResearchResearch themes
Professor Fujimoto aims to elucidate the pathology of, and establish treatments for, intractable connective tissue diseases and immune disorders, including scleroderma and dermatomyositis. Research is carried out by each faculty member from different angles, such as autoantibodies, B cells, T cells in the skin, and skin bacteria.
*Illustrative imageConnective Tissue Diseases and Autoantibodies
The lab investigates the mechanisms underlying systemic sclerosis, dermatomyositis, and related diseases from both basic and clinical perspectives. For dermatomyositis, it has published pioneering results on classifying the disease into subsets based on specific autoantibodies.
*Illustrative imageB Cells and Autoimmune Diseases
Focusing on CD19 and CD22, molecules on the surface of B cells, the lab studies how signals are transmitted and how this relates to autoimmune diseases. It also investigates the role that regulatory B cells (Bregs), which suppress immune responses, play in skin diseases.
*Illustrative imageThe Role of T Cells That Stay in the Skin
The lab investigates how skin-resident memory T cells affect the pathology of various skin diseases. Aiming to develop therapeutic drugs centered on restoring normal T cell function, it also explores how T cell function changes with aging.
*Illustrative imageSkin Microbiota and Inflammation
In chronic inflammatory skin diseases such as atopic dermatitis, the lab investigates the relationship between the resident skin microbiota and the pathogenic bacteria that cause inflammation. Using mouse models and analysis of bacterial genes, it explores how a disrupted microbiota triggers quorum sensing in pathogenic bacteria, leading to toxin production and skin inflammation.
MembersFaculty
The lab's members consist of Professors, Lecturers, Assistant Professors, project faculty and researchers, Visiting Professors, residents, graduate students, and registered clinical physicians.As of 2026
- ProfessorManabu Fujimoto
- ProfessorYumi Matsuoka
- Project ProfessorMari Kaneda
- LecturerIkuko Ueda
- LecturerEiji Kiyohara
- LecturerYukinobu Nakagawa
- Assistant ProfessorNoriko Arase
- Assistant ProfessorKyoko Tonomura
- Assistant ProfessorYu Matsumura
- Assistant ProfessorKazunori Yokoi
- Project Associate ProfessorShiho Mori
- Project Associate ProfessorYasushi Kikuchi
- Project LecturerHironori Ishizuka
- Project LecturerHanako Yoshioka
- Project LecturerSeitaro Nakagawa
- Project Assistant ProfessorYuriko Yamazaki
- Project Assistant ProfessorHiroyuki Morisaka
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Dermatology - Skin -- Smart-Servier” Laboratoires Servier / CC BY-SA 3.0 (cropped)
- Connective Tissue Diseases and Autoantibodies: “Immunofluorescence staining for IgG along glomerular capillary loops” Adel.stoyanova / CC BY-SA 4.0 (cropped)
- B Cells and Autoimmune Diseases: “Human B Lymphocyte - NIAID” NIAID / CC BY 2.0 (cropped)
- The Role of T Cells That Stay in the Skin: “T Lymphocyte ( )” NIAID / CC BY 2.0 (cropped)
- Skin Microbiota and Inflammation: “Microbes (bacteria - staphylococcus aureus) - the yellowish dots there, after incubating a urine culture for 24hrs; from in a medical laboratory in Abuja, Nigeria” Frankincense Diala / CC0 (cropped)
- Related lab (Hospital Clinical Laboratory Medicine Lab): “Clinical Chemistry Analyzer , Клинички биохемиски анализатор 1” Делфина / CC BY-SA 4.0 (cropped)
- Related lab (Immune Regulation Lab): “Intestinal bacteria culture test tube” Fumikas Sagisavas / CC0 (cropped)
- Related lab (Host Defense Lab): “House Dust Mite” Employee of US Government / Public domain (cropped)
- Related lab (Neurology Lab): “Neuron (100x magnification)” Ns takes photos / CC BY 4.0 (cropped)
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