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Gastroenterology and Hepatology Lab
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The lab explores diseases of the liver, biliary tract and pancreas, and digestive tract from both basic and clinical perspectives.
AboutAbout the lab
Gastroenterology where people grow, knowledge is created, and connections reach the world
The lab covers liver diseases, biliary and pancreatic diseases, and gastrointestinal diseases, and conducts both basic and clinical research.
Research is carried out by several groups, including those on hepatocyte death and the microenvironment, biliary and pancreatic endoscopy, and clinical research on liver disease.
Its top page states the aim of contributing to the health and welfare of people around the world through cutting-edge research and clinical care.
Key terms
- Hepatic stellate cell
- A type of cell in the liver. The lab studies its involvement in chronic liver disease, such as fibrosis.
- Microenvironment
- The surrounding environment of cells, including immune cells. The lab studies its relationship to how diseases progress.
- EUS/ERCP
- Abbreviations for endoscopic ultrasonography (EUS) and endoscopic retrograde cholangiopancreatography (ERCP), an endoscopic examination of the bile and pancreatic ducts.
- IPMN
- A type of tumor that develops in the pancreas (intraductal papillary mucinous neoplasm). The lab treats it as a precancerous lesion of pancreatic cancer.
NewsLab news
Information session on initial residency training held (Oct. 26, for 4th- and 5th-year medical students)
A paper by a Project Assistant Professor et al. was published in Crohn's & Colitis 360
A paper by a graduate student was published in Cellular and Molecular Gastroenterology and Hepatology
A paper by a graduate student and an Assistant Professor was published in Hepatology Research
A paper was published in Endoscopy (E-video)
ResearchResearch themes
Multiple research groups conduct basic and clinical research on liver diseases, biliary and pancreatic diseases, and gastrointestinal diseases. The lab also pursues multicenter collaborative studies, aiming to generate evidence that can be returned to clinical practice.
*Illustrative imageChronic liver disease explored through hepatocyte death
Starting from hepatocyte death, the lab studies how chronic liver disease progresses to inflammation, fibrosis, and carcinogenesis. Focusing on the microenvironment, including hepatic stellate cells and immunity, it searches for factors that drive disease progression as therapeutic targets.
*Illustrative imageTackling biliary and pancreatic cancer with endoscopy
Biliary and pancreatic cancers have a poor prognosis and are an area with large unmet medical needs. Centered on EUS/ERCP, the lab advances care that combines diagnosis, endoscopic treatment, drug therapy, and genetic testing, and builds evidence through multicenter studies.
*Illustrative imageAnswering questions about liver disease from daily clinical practice
Starting from questions about liver disease that arise in daily practice, the lab tests them in multicenter studies through the Osaka Liver Forum (OLF) and shares the evidence with the world. It also shares samples such as serum and liver tissue to research biomarkers that predict cancer development and treatment response.
*Illustrative imageHalting the progression of pancreatic and liver diseases
The lab studies the course from inflammation to fibrosis, precancerous lesions, and cancer in the pancreas and liver, aiming to stop that progression. In the pancreas, it focuses on precancerous lesions centered on IPMN; in the liver, on the roles of p53 and sinusoidal endothelial cells.
MembersFaculty
The lab's members consist of faculty, concurrent faculty, staff physicians, and members studying overseas.As of 2026
- ProfessorTakahiro Kodama
- Associate ProfessorHayato Hikita
- LecturerYoshihito Hayashi
- LecturerYoshiki Tsujii
- Internal LecturerYoshinobu Saito
- Internal LecturerTeppei Yoshioka
- Internal LecturerYuki Tabata
- Assistant ProfessorYuki Makino
- Assistant ProfessorKazuhiro Murai
- Assistant ProfessorTeiji Sakane
- Project Assistant ProfessorTakeo Yoshihara
- Project Assistant ProfessorKatsuhiko Sato
- Project Assistant ProfessorRyotaro Uema
- Project Assistant ProfessorKumiko Shirai
- Project Assistant ProfessorSatoshi Shigeno
- Project Assistant ProfessorYuta Myojin
- Project Assistant ProfessorYuriko Otake
- Project Assistant ProfessorKazuki Maesaka
- ProfessorKenji Watanabe
- ProfessorTakahiro Inoue
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Abdominal pain” Robystarm07 / CC0 (cropped)
- Chronic liver disease explored through hepatocyte death: “Non-alcoholic fatty liver disease1” Nephron / CC BY-SA 3.0 (cropped)
- Tackling biliary and pancreatic cancer with endoscopy: “Endoscopic retrograde cholangiopancreatography (ERCP)” Kel898 / CC BY-SA 4.0 (cropped)
- Answering questions about liver disease from daily clinical practice: “Liver Fibroscan Transient Elastography LSM CAP Navi Mumbai” Goleisureintl / CC BY 4.0 (cropped)
- Halting the progression of pancreatic and liver diseases: “3D Medical Animation Acute Pancreatitis” https://www.scientificanimations.com / CC BY-SA 4.0 (cropped)
- Related lab (Environmental Response Pharmacology Lab): “Microscopy in bloom” Saraifveiga / CC BY 4.0 (cropped)
- Related lab (International Future Medicine Lab): “Female health workers in India ( )” CDC Global / CC BY 2.0 (cropped)
- Related lab (Hematology and Oncology Lab): “Blood cells under the microscope 01” Korinna / CC BY 4.0 (cropped)
- Related lab (Sports Medicine Lab): “Students analyze pulmonary results in their Sports Medicine class” JFarbarik / CC BY-SA 4.0 (cropped)
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