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Hematology and Oncology Lab
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The lab creates new treatments through clinical care and research on blood diseases.

AboutAbout the lab
Creating new treatments that are effective worldwide
The lab provides clinical care for blood diseases such as leukemia and multiple myeloma, and conducts fundamental research that leads to new treatments.
As the hematology and oncology department of Osaka University Hospital, it treats all blood diseases, including with hematopoietic stem cell transplantation.
It also pursues fundamental research toward new treatments that are effective worldwide, advancing work such as the development of CAR-T cell therapy.
Visits by students and residents are accepted at any time; please consult the lab by email.
Key terms
- CAR-T cell therapy
- An immune cell therapy that targets antigens on the surface of blood cancer cells.
- Hematopoietic stem cell transplantation
- A treatment that transplants hematopoietic stem cells, which continuously supply blood cells, aiming to cure blood diseases.
- Immune thrombocytopenia
- A disease in which the platelet count falls because of autoimmunity. Abbreviated as ITP.
- Hematopoietic microenvironment
- The environment surrounding hematopoietic stem cells in the bone marrow. Also called the niche.
NewsLab news
View More ↗ResearchResearch themes
To advance the treatment of blood diseases, the lab conducts fundamental research toward new treatments that are effective worldwide, alongside clinical care that includes hematopoietic stem cell transplantation. Research is carried out by groups on immune cell therapy, platelet disorders, red blood cell disorders, hematopoietic stem cells and the niche, and clinical research.
*Illustrative imageImmune cell therapy targeting blood cancers
The lab identifies surface antigens specifically expressed on blood cancer cells and develops CAR-T cell therapy that targets them. Using samples from treated patients, it investigates why the therapy worked or did not work.
*Illustrative imagePlatelet diseases and the mechanisms of hemostasis
The lab works to clarify the pathology of immune thrombocytopenia and improve its diagnosis, aiming to improve treatment. Focusing on GPIIb-IIIa, a receptor required for platelet aggregation, it also studies the mechanisms that regulate platelet activation.
*Illustrative imageRed blood cell disorders and complement-related diseases
Through research on hemolytic anemia, centered on paroxysmal nocturnal hemoglobinuria, the lab works to elucidate how stem cell clones expand under bone marrow failure, to clarify the pathology of diseases involving complement, and to develop treatments.
*Illustrative imageHematopoietic stem cells and the bone marrow environment
The lab studies the properties of hematopoietic stem cells and the hematopoietic microenvironment of the bone marrow. Building on analysis of normal hematopoiesis, it examines their links to hematologic malignancies such as leukemia and multiple myeloma, aiming for new therapies that control blood cancers.
MembersFaculty
The lab's members consist of faculty, invited faculty, staff physicians including graduate students, specialty residents, clinical registered physicians, technical assistants, and administrative assistants.As of 2026
- ProfessorNaoki Hosen
- Hospital Professor (Department of Transfusion and Cell Therapy)Hisashi Kato
- Associate Professor (Chemotherapy Department)Kentaro Fukushima
- LecturerMichiko Ichii
- LecturerYasutaka Ueda
- Assistant Professor (Intra-Faculty Lecturer)Tomoaki Ueda
- Assistant Professor (Intra-Faculty Lecturer)Shinsuke Kusakabe
- Assistant Professor (Intra-Faculty Lecturer)Hidenori Kasahara
- Assistant Professor (Intra-Faculty Lecturer)Akihisa Hino
- Assistant ProfessorKeigo Akuta
- Assistant ProfessorKumi Shibata
- Project Assistant ProfessorYuka Amemiya
- Project Assistant ProfessorWataru Nakahara
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Blood cells under the microscope 01” Korinna / CC BY 4.0 (cropped)
- Immune cell therapy targeting blood cancers: “CAR T-Cell Therapy” National Cancer Institute (NCI) / Public domain (cropped)
- Platelet diseases and the mechanisms of hemostasis: “3D render of a human blood clot formed in vitro under flow” Joanne Mitchell / CC BY-SA 4.0 (cropped)
- Red blood cell disorders and complement-related diseases: “Warm autoimmune hemolytic anemia blood smear” Spicy / CC BY-SA 4.0 (cropped)
- Hematopoietic stem cells and the bone marrow environment: “Erythrocyte development from bone marrow” David Nascari and Alan Sved / CC BY-SA 4.0 (cropped)
- Related lab (Respiratory Medicine and Clinical Immunology Lab): “Miner spirometry ( )” National Institute for Occupational Safety and Health (NIOSH) from USA / Public domain (cropped)
- Related lab (Infection Control Lab): “Electron micrograph of two coronaviruses” Dr Graham Beards / CC BY-SA 4.0 (cropped)
- Related lab (Geriatric and General Internal Medicine Lab): “Nurse in geriatry” I Craig from Glasgow, Scotland / CC BY 2.0 (cropped)
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