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Geriatric and General Internal Medicine Lab
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The lab integrates geriatric medicine and general medicine to advance clinical care and research for older adults.
AboutAbout the lab
Creating new geriatric medicine and new care for older adults
The lab is a clinical department that integrates geriatric medicine and general medicine, working on both clinical care and research for older patients.
Research is carried out by groups on dementia, frailty and sarcopenia, and hypertension and aging, together with a general medicine group.
The shared goal is to achieve healthy longevity and contribute to building a vibrant, bright super-aged society.
The lab also focuses on training physicians who combine specialized skills in geriatric care and general medicine with a research mindset.
Key terms
- Frailty
- A state in which the mind and body weaken with aging. It refers to frailty in older adults.
- Sarcopenia
- A condition in which skeletal muscle mass and strength decline with aging or other causes.
- Myokine
- A general term for substances released from skeletal muscle. IL-15 is one of them.
NewsLab news
A paper by Associate Professor Iwashima et al. was published in Journal of clinical hypertension (Greenwich, Conn.)
A paper by Associate Professor Iwashima et al. was published in Geriatrics & gerontology international
A paper by Professor Yamamoto et al. was published in GeroScience
A paper by Professor Yamamoto et al. was published in Journal of cardiology
A paper by Assistant Professor Hara et al. was published in Genes to cells : devoted to molecular & cellular mechanisms
ResearchResearch themes
Research at the lab is carried out by groups focused on aging-related topics and by a general medicine group. They study aging and its associated diseases, working toward new discoveries and the development of treatments. The shared goal is healthy longevity. Here, research themes are introduced from the page of the Frailty and Sarcopenia (Geriatric Metabolism and Diabetes) lab (written around 2022).
*Illustrative imageBasic research on muscle and myokines
Using cell experiments, the lab examines how IL-15, a type of myokine, improves glucose metabolism. It has also found that IL-15 signaling is important for the differentiation of myoblasts into myotubes.
*Illustrative imageObservational studies of inpatients and outpatients
The lab collects data through tests such as muscle strength assessments in outpatient clinics and wards, and has shown that past exercise habits affect physical function and fall risk. In joint research with gastrointestinal surgery, it has become clear that preoperative tests in older patients with gastrointestinal cancer can stratify postoperative risk.
*Illustrative imageInterventional studies using non-drug therapies
Using randomized controlled trials (RCTs), the lab examines two questions: how preoperative nutrition and exercise interventions for gastrointestinal cancer patients with frailty affect postoperative complications and postoperative mental and physical function, and how exercise interventions of different intensities affect skeletal muscle indicators in older diabetic patients with frailty.
*Illustrative imageInterventional studies using drugs
The lab examined the effects of the SGLT2 inhibitor ipragliflozin in older diabetic patients with chronic heart failure in an RCT. It has also reported a clinical study testing the effects of NMN in older diabetic patients with physical frailty.
MembersFaculty
The lab's members include faculty, staff physicians, PhD students, international students, members based at overseas research institutions, clinical professors, part-time lecturers, and invited faculty.As of 2024
- ProfessorKoichi Yamamoto
- Associate ProfessorYoshio Iwashima
- LecturerYoichi Takami
- LecturerHiroshi Koriyama
- Lecturer, Faculty of MedicineAkihisa Hara
- Lecturer, Faculty of MedicineKazuhiro Motoyuki
- Lecturer, Faculty of MedicineTaku Fujimoto
- Assistant ProfessorNoriyuki Baba
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Nurse in geriatry” I Craig from Glasgow, Scotland / CC BY 2.0 (cropped)
- Basic research on muscle and myokines: “Multinuclear muscle fiber cells and some associated mononuclear cells” MethylC5 / CC BY-SA 4.0 (cropped)
- Observational studies of inpatients and outpatients: “Hand dynamometer” Ashashyou / CC0 (cropped)
- Interventional studies using non-drug therapies: “Gestational diabetes kit” Jessica Merz from Novato, USA / CC BY 2.0 (cropped)
- Interventional studies using drugs: “Cardiovascular system - Diastolic heart failure -- Smart-Servier” Laboratoires Servier / CC BY-SA 3.0 (cropped)
- Related lab (Advanced AI Medicine Lab): “CSIRO ScienceImage 2465 Sequencing DNA” Health Sciences and Nutrition, CSIRO / CC BY 3.0 (cropped)
- Related lab (International Future Medicine Lab): “Female health workers in India ( )” CDC Global / CC BY 2.0 (cropped)
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