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Organ System Creation Lab
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The lab creates artificial organs from human iPS cells to open new frontiers in medicine.
AboutAbout the lab
Pioneering new medicine through organ system creation.
The Organ System Creation Lab researches how to create three-dimensional organs, known as organoids (artificial organs), from human iPS cells.
In end-stage organ failure, where transplantation is the only hope, the shortage of donor organs is a serious problem.
The lab conducts its research to take on this challenge.
By using artificially induced organs, the lab aims to open paths toward personalized medicine, drug discovery, and regenerative medicine.
At Osaka University's Graduate School of Medicine, the lab is presented as the Department of Organ System Creation within the Division of Genome Biology.
Key terms
- Organoid
- An artificial organ built in three dimensions from human iPS cells
- End-stage organ failure
- The final stage of various diseases, in which transplantation is the only hope
- Disease modeling system
- A system that reproduces conditions such as nonalcoholic steatohepatitis (NASH) and drug-induced liver injury in artificial organs in order to understand them
ResearchResearch themes
To create treatments for end-stage organ failure, the lab develops cell manipulation technologies for building complex organs from iPS cells. It aims to apply the organs it creates to personalized medicine, drug discovery, and regenerative medicine.
Creating complex organs from iPS cells
Drawing on the latest findings in stem cell biology and developmental biology, the lab develops cell manipulation technologies for forming complex organs from human iPS cells.
*Illustrative imageModeling diseases to support drug discovery
Through disease modeling systems, the lab reproduces and studies conditions such as nonalcoholic steatohepatitis (NASH) and drug-induced liver injury, aiming to contribute to drug development.
*Illustrative imageApproaching personalized medicine with artificial organs
By combining approaches such as information science and using artificial organ models, the lab investigates the diversity of human diseases. It aims to realize personalized medicine.
*Illustrative imageRegenerative medicine for liver disease
Through artificial organs and transplantation medicine, the lab explores the potential of regenerative medicine for severe liver disease.
MembersFaculty
- ProfessorTakanori Takebe
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Binder CB 210 incubator interior” Shinryuu / Public domain (cropped)
- Modeling diseases to support drug discovery: “Fatty liver 2” Sameem Arif / CC BY-SA 4.0 (cropped)
- Approaching personalized medicine with artificial organs: “Organoid during development ( )” NIH Image Gallery from Bethesda, Maryland, USA / Public domain (cropped)
- Regenerative medicine for liver disease: “Left Liver Transplant” Aphelpsmd / CC BY-SA 4.0 (cropped)
- Related lab (Neuroinformatics Lab): “EEG Experiment (cropped)” Flexagoon / CC0 (cropped)
- Related lab (Cardiovascular Medicine Lab): “Mammal heart model 04- FMVZ USP-06” Wagner Souza e Silva / CC BY-SA 4.0 (cropped)
- Related lab (Ophthalmology Lab): “Slit lamp eye examination” OKJaguar / CC BY-SA 4.0 (cropped)
- Related lab (Thoracic Surgery Lab): “Antique surgical instruments, AM Epidauros, 091145” Zde / CC BY-SA 4.0 (cropped)
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