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Pathophysiological Function Analysis Lab
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The lab develops diagnostic and therapeutic drugs by using imaging from outside the body to observe how molecules behave inside it.
AboutAbout the lab
Seeing inside the living body at the molecular level.
Living organisms function through the interactions of many molecules, so understanding their functions requires analysis at the molecular level.
The Pathophysiological Function Analysis Lab uses photon-based technologies to develop molecular imaging methods that visualize, in real time and from outside the body, the molecular interactions taking place inside a living body.
Building on this, the lab clarifies biological functions and the causes of disease, and develops diagnostic and therapeutic drugs based on the characteristics of disease states.
Key terms
- Molecular imaging
- A method of visualizing the movement and amount of specific molecules inside the body from outside the body.
- Molecular probe
- A compound that binds to a specific molecule and acts as a marker showing where that molecule is.
- Radiopharmaceutical
- A drug that contains a radiation-emitting substance and is used for diagnostic imaging and treatment.
- Amyloid
- An abnormal aggregation of proteins that accumulates in the brain in conditions such as Alzheimer's disease.
ResearchResearch themes
Targeting brain diseases, heart diseases, and cancer, the lab connects the results of molecular imaging to clinical diagnosis and treatment.
*Illustrative imageDevelopment of molecular imaging methods
Targeting neurodegenerative diseases and tumors, the lab designs and develops highly sensitive molecular probes. It works on imaging the process by which amyloid and tau protein accumulate in Alzheimer's disease, and on evaluating drug-induced changes and therapeutic effects.
*Illustrative imageCreation of diagnostic imaging agents and radiotherapeutic drugs
The lab develops radiopharmaceuticals that target the environments and proteins specific to brain diseases, myocardial diseases, and tumors.
MembersFaculty
- ProfessorMasahiro Ono
- LecturerHiroyuki Watanabe
- Assistant ProfessorKazuma Nakashima
- Assistant ProfessorKosuke Saito
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Berkeley 60-inch cyclotron” Department of Energy. Office of Public Affairs / Public domain (cropped)
- Development of molecular imaging methods: “Beta-Amyloid Plaques and Tau in the Brain ( )” NIH Image Gallery from Bethesda, Maryland, USA / Public domain (cropped)
- Creation of diagnostic imaging agents and radiotherapeutic drugs: “Radiopharmaceuticals” National Cancer Institute (NCI) / Public domain (cropped)
- Related lab (Systems Chemotherapy and Molecular Regulation Lab): “Ecological Trail Garden of Medicinal and Aromatic Plants and South China Medicinal Plants Garden )” LN9267 / CC BY-SA 4.0 (cropped)
- Related lab (Mathematical Therapeutics Lab): “Iodine pills” Mx. Granger / CC0 (cropped)
- Related lab (Systems Biology Lab): “Circadian rhythm labeled” National Institute of General Medical Sciences / Public domain (cropped)
- Related lab (Kyoto University Ogata Lab (Microbial Ecology, Evolution, and Bioinformatics)): “Cryoelectron microscopy of the Giant Mimivirus - journal.pbio.1000092.g005” Xiao C, Kuznetsov YG, Sun S, Hafenstein SL, Kostyuchenko VA, et al. (2009) / CC BY 2.5 (cropped)
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