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Pharmaceutical Functional Analysis Lab
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The lab uses mass spectrometry to measure the metabolism of living organisms comprehensively and to explore what its diversity means.
AboutAbout the lab
Metabolic diversity and its biological significance.
Launched in 2021, the lab pursues systems biology based on omics science centered on mass spectrometry.
Combining genetics, biochemistry, mass spectrometry, and information science, the lab studies a wide range of organisms, including animals, microorganisms, and plants, through metabolism, which lies at the heart of life activity.
Key terms
- Mass spectrometry
- A method that precisely measures the mass of molecules to determine which substances are present and in what amounts
- Omics
- A general term for research that comprehensively investigates genes, proteins, metabolites, and other molecules as a whole
- Metabolome
- The complete set of metabolites found in a cell or an organism
- Systems biology
- Research that seeks to understand life as a system in which many molecules are interconnected
ResearchResearch themes
To uncover the diversity of metabolites and its biological significance, the lab approaches the question from both measurement technology and information science.
*Illustrative imageMeasuring metabolic diversity
Using the metabolome as an entry point, the lab works to elucidate the diversity of metabolites and its biological significance. It develops new measurement methods for metabolomics and lipidomics.
*Illustrative imageSoftware for omics data
To bring out the full value of omics data, the lab develops its own programs. The software is released on GitHub, with the aim of benefiting the broader research community.
MembersFaculty
- ProfessorHiroshi Tsugawa
- Associate ProfessorMasaru Hoshino
- Assistant ProfessorChenchen Liu
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Liquid chromatograph with mass spectrometer in CAFIA laboratory, Czech Republic” Sarka Na kopci / CC BY-SA 4.0 (cropped)
- Measuring metabolic diversity: “Construction-of-Phosphorus-Dependent-Metabolic-Network-Network-expansion-simulation-was” Tian Tian, Xin-Yi Chu, Yi Yang, Xuan Zhang, Ye-Mao Liu, Jun Gao, Bin-Guang Ma, and Hong-Yu Zhang / CC BY 4.0 (cropped)
- Software for omics data: “Code on computer monitor (Unsplash)” Markus Spiske markusspiske / CC0 (cropped)
- Related lab (生体分子計測学): “Mass spectrometer quadrupole” Fulvio314 / CC BY-SA 3.0 (cropped)
- Related lab (構造生物薬学): “OGA crystal structure dimer” Scheng23 / CC BY-SA 4.0 (cropped)
- Related lab (京都大学 緒方研究室
（微生物生態学・進化学・バイオインフォマティクス） ): “Cryoelectron microscopy of the Giant Mimivirus - journal.pbio.1000092.g005” Xiao C, Kuznetsov YG, Sun S, Hafenstein SL, Kostyuchenko VA, et al. (2009) / CC BY 2.5 (cropped) - Related lab (生命知識工学): “Hist1 Biological Network Graph” LuAtOU / CC0 (cropped)
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