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Aging and Infection Control Lab
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The lab uses nematodes and mice to explore how aging, infection, and commensal microbes are connected.
AboutAbout the lab
Controlling aging and infection through commensal microbes.
The Division of Aging and Infection Control uses the nematode C. elegans and mice as model organisms to study the mechanisms of aging and infection and ways to control them.
Inflammation is increasingly recognized as deeply linked not only to infection but also to a variety of chronic diseases, and the lab is also looking at the possibility of suppressing inflammation with gut bacteria.
Key terms
- C. elegans
- A nematode about 1 mm long. Its short lifespan makes it a common model organism in aging research
- Commensal microbiota
- The community of many kinds of microbes that live permanently in places such as the gut and skin
- Inflammatory bowel disease
- A disease in which chronic inflammation persists in the intestine, such as ulcerative colitis and Crohn's disease
- Mitochondria
- Organelles in the cell that produce energy; they are closely linked to aging
ResearchResearch themes
The lab aims to clarify how commensal microbiota in the gut and skin interact with their host, and to establish control methods that benefit human health.
*Illustrative imageInteractions between commensal microbiota and the host
Using nematodes and mice, the lab has clarified part of the mechanisms by which the commensal microbiota living in the gut and on the skin interact with the host.
*Illustrative imageGut bacteria that suppress inflammation
Preventing inflammatory bowel disease and relieving its symptoms are important challenges. The lab has found strains of E. coli that suppress the induction of inflammation-causing substances, and is searching among the many kinds of gut bacteria for those that reduce inflammation.
*Illustrative imageMitochondria and lifespan
Mitochondria are closely tied to aging and are a promising target for controlling it. In a screen using nematodes, the lab identified a pharmaceutical compound that activates the mitochondrial stress response and extends lifespan.
MembersFaculty
- ProfessorEriko Kage-Kage-Nakadai
- Assistant ProfessorYoshihiko Tanimoto
- Assistant ProfessorMisaki Okahata
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Report an errorAbout the images
For images provided to us or used with permission, the source is listed on each line. Wikimedia Commons images are illustrative and were not taken at the lab (they are cropped). Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Caenorhabditis elegans hermaphrodite adult-en” KDS444 / CC BY-SA 3.0 (cropped)
- Interactions between commensal microbiota and the host: “E. coli Bacteria ( )” NIAID / Public domain (cropped)
- Gut bacteria that suppress inflammation: “Escherichia coli 2” U.S. Department of Health & Human Services: Centers for Disease Control and Prevention / Public domain (cropped)
- Mitochondria and lifespan: “Mitochondria 7 -- Smart-Servier” Laboratoires Servier / CC BY-SA 3.0 (cropped)
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